|
|
|
|
|
1.
|
Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine
Jonghwan
Kim,
Stuart
H
Orkin
Genome Medicine 2011, 3:75 (29 November 2011)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
Jonghwan Kim and Stuart Orkin review recent genome-scale and systems approaches to understand the regulatory networks that are common to embryonic stem (ES) cells and cancer.
|
|
|
2.
|
Transcriptomic analysis of pluripotent stem cells: insights into health and disease
Jia-Chi
Yeo,
Huck-Hui
Ng
Genome Medicine 2011, 3:68 (27 October 2011)
This article is part of a collection on
Focus on stem cells
Abstract | Full text | PDF | PubMed
|
Editor’s summary
Jia-Chi Yeo and Huck-Hui Ng review recent progress in understanding the transcriptional networks of pluripotent stem cells, and discuss how this knowledge has impacted translational medicine.
|
|
|
3.
|
Stem cell approaches for diabetes: towards beta cell replacement
Gordon
C
Weir,
Claudia
Cavelti-Weder,
Susan
Bonner-Weir
Genome Medicine 2011, 3:61 (27 September 2011)
This article is part of a collection on
Focus on stem cells
Abstract | Full text | PDF | PubMed
|
Editor’s summary
Gordon Weir at al. review advances in understanding diabetes at the genomic level, and discuss how stem-cell-based approaches might be used for replacing beta cells and for treating the various forms of diabetes.
|
|
|
4.
|
Capturing Alzheimer's disease genomes with induced pluripotent stem cells: prospects and challenges
Mason
A
Israel,
Lawrence
SB
Goldstein
Genome Medicine 2011, 3:49 (27 July 2011)
This article is part of a collection on
Focus on stem cells
Abstract | Full text | PDF | PubMed
|
Editor’s summary
Mason Israel and Lawrence Goldstein review the prospects and challenges for studying Alzheimer's disease genes and modeling pathogenesis using patient-derived induced pluripotent stem cells (iPSCs).
|
|
|
5.
|
Public perception of stem cell and genomics research
M William
Lensch
Genome Medicine 2011, 3:44 (6 July 2011)
This article is part of a collection on
Focus on stem cells
Abstract | Full text | PDF | PubMed
|
Editor’s summary
William Lensch muses on factors influencing the public perception of translational stem cell and genomics research, for which public and patient engagement is increasingly important.
|
|
|
6.
|
microRNAs become macro players in somatic cell reprogramming
Tamer
T
Onder,
George
Q
Daley
Genome Medicine 2011, 3:40 (22 June 2011)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
Onder and Daley highlight a new study by Morrisey and colleagues showing that embryonic stem cells can be reprogrammed entirely with microRNAs, without the use of transcription factors.
|
|
|
7.
|
Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease
Alvaro
Rada-Iglesias,
Joanna
Wysocka
Genome Medicine 2011, 3:36 (7 June 2011)
This article is part of a collection on
Focus on stem cells
Abstract | Full text | PDF | PubMed
|
Editor’s summary
Wysocka and Rada-Iglesias review advances in epigenomic profiling of human pluripotent stem cells, highlighting the roles of regulatory elements and the implications for disease.
|
|
|
8.
|
Genomic and stem cell policy issues: more alike than different?
Mary
A
Majumder
Genome Medicine 2011, 3:35 (7 June 2011)
This article is part of a collection on
Focus on stem cells
Abstract | Full text | PDF | PubMed
|
Editor’s summary
Mary Majumder muses on the convergence of stem cell and genomics policy discussions, highlighting common areas of concern such as communication, consent, commercialization and clinical integration.
|
|
|
9.
|
Genome Medicine: stem cells, genomics and translational research
Stuart
H
Orkin
Genome Medicine 2011, 3:34 (7 June 2011)
This article is part of a collection on
Focus on stem cells
Abstract | Full text | PDF | PubMed
|
Editor’s summary
An editorial by Guest Editor Stuart Orkin introduces this new series of articles, highlighting progress in genomic-scale studies of stem cells and cellular reprogramming that could impact medicine.
|
|
|
10.
|
Stem cells in drug discovery, regenerative medicine and cancer
C Bart
Rountree
Genome Medicine 2011, 3:15 (14 March 2011)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
A report on the Stem Cells World Congress held in San Diego, USA, 24-25 January 2011
|
|
|
11.
|
Role of cancer stem cells in hepatocarcinogenesis
Bo
Wang,
Samson
T
Jacob
Genome Medicine 2011, 3:11 (22 February 2011)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
Cancer stem cells have a key role in liver carcinogenesis, and understanding their characteristics and function could lead to potential applications in hepatocellular carcinoma therapeutics.
|
