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1.
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Circulating microRNAs as biomarkers - True Blood?
Nathalie
Schöler,
Christian
Langer,
Florian
Kuchenbauer
Genome Medicine 2011, 3:72 (23 November 2011)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Florian Kuchenbauer and colleagues highlight a recent study revealing that blood-borne microRNA expression data or the "miRNome" could be a powerful tool for the blood-based diagnosis of disease.
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2.
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RNA-Seq and find: entering the RNA deep field
Adam
Roberts,
Lior
Pachter
Genome Medicine 2011, 3:74 (22 November 2011)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Lior Pachter and Adam Roberts discuss the advantages of a new method, RNA CaptureSeq, for the detection of low-abundance transcripts potentially important for disease, within the RNA "deep field".
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3.
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Why have protein biomarkers not reached the clinic?
Samir
M
Hanash
Genome Medicine 2011, 3:66 (26 October 2011)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Samir Hanash reflects on the reasons why there is a paucity of approved biomarkers for use in clinics, despite substantial advances in the understanding of the molecular basis of disease.
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4.
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PPAR action in insulin resistance unraveled by metabolomics: potential clinical implications
Andrew
D
Patterson,
Jeffrey
M
Peters
Genome Medicine 2011, 3:54 (23 August 2011)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Patterson and Peters highlight a new study by Griffin and colleagues showing different effects of two peroxisome proliferator activated receptors on fatty acid metabolism.
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5.
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Proteomics paves the way for Q fever diagnostics
Malgorzata
Kowalczewska,
Zuzana
Sekeyová,
Didier
Raoult
Genome Medicine 2011, 3:50 (30 July 2011)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Raoult and colleagues review advances in Coxiella burnetti proteomics, highlighting how these approaches are allowing the identification of biomarkers for improved diagnosis of Q fever.
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6.
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Biomarkers in solid organ transplantation: establishing personalized transplantation medicine
Silke
Roedder,
Matthew
Vitalone,
Purvesh
Khatri,
Minnie
M
Sarwal
Genome Medicine 2011, 3:37 (8 June 2011)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Minnie Sarwal and colleagues review the rocky road to regulatory approval in the search for biomarkers for organ transplants that will help predict the chances of success and increase graft survival.
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7.
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Future medical applications of single-cell sequencing in cancer
Nicholas
Navin,
James
Hicks
Genome Medicine 2011, 3:31 (31 May 2011)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Navin and Hicks provide an overview of recent methods for sequencing in single cells and discuss how this approach will be useful for detection of copy number variation for improving cancer outcomes.
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8.
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Metabolome in schizophrenia and other psychotic disorders: a general population-based study
Matej
Orešič,
Jing
Tang,
Tuulikki
Seppänen-Laakso,
Ismo
Mattila,
Suoma
E
Saarni,
Samuli
I
Saarni,
Jouko
Lönnqvist,
Marko
Sysi-Aho,
Tuulia
Hyötyläinen,
Jonna
Perälä,
Jaana
Suvisaari
Genome Medicine 2011, 3:19 (23 March 2011)
Abstract | Full text | PDF | PubMed
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Editor’s summary
A population-based metabolomics study in Finland reveals disease-specific metabolic abnormalities associated with schizophrenia, compared with other psychotic disorders.
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9.
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Gut microbiome-host interactions in health and disease
James
M
Kinross,
Ara
W
Darzi,
Jeremy
K
Nicholson
Genome Medicine 2011, 3:14 (4 March 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
The gut microbiome plays an important role in human disease and further understanding microbiome activity is crucial for the development of future personalized treatment strategies.
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10.
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Genome Medicine: past, present and future
Charles
Auffray,
Timothy
Caulfield,
Muin
J
Khoury,
James
R
Lupski,
Matthias
Schwab,
Timothy
Veenstra
Genome Medicine 2011, 3:6 (31 January 2011)
Abstract | Full text | PDF | PubMed
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Editor’s summary
As Genome Medicine reaches its second anniversary, our Section Editors identify the most exciting recent breakthroughs and offer their opinions on what the future of genomic medicine might hold.
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