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#genepidemiology

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	1.	Research highlight Targeted next-generation sequencing for routine clinical screening of mutations Jamie MJ Weaver, Paul AW Edwards Genome Medicine 2011, 3:58 (12 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Weaver and Edwards highlight a new single-step targeted sequencing approach to detect mutations in the breast cancer gene BRCA1, towards the development of a novel clinical diagnostic protocol.
	2.	Research Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort Katherine R Smith, Vijayaprakash Suppiah, Kate O'Connor, Thomas Berg, Martin Weltman, Maria Abate, Ulrich Spengler, Margaret Bassendine, Gail Matthews, William L Irving, Elizabeth Powell, Stephen Riordan, Golo Ahlenstiel, Graeme J Stewart, Melanie Bahlo, Jacob George, David R Booth, Genome Medicine 2011, 3:57 (31 August 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Novel variants in the IL28B gene region, which predict lack of response to conventional treatment of hepatitis C virus, are identified through massively parallel sequencing using pooled DNA.
	3.	Musings Are diagnostic and public health bacteriology ready to become branches of genomic medicine? Mark J Pallen, Nicholas J Loman Genome Medicine 2011, 3:53 (23 August 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary As next-generation sequencing technologies continue to evolve, Mark Pallen and Nicholas Loman muse on the impact of whole genome sequencing on diagnostic and public health microbiology.
	4.	Research Predictive genetic testing for the identification of high-risk groups: a simulation study on the impact of predictive ability Raluca Mihaescu, Ramal Moonesinghe, Muin J Khoury, A Janssens Genome Medicine 2011, 3:51 (28 July 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Analysis of the predictive ability of risk models to identify high-risk groups for complex diseases highlights the importance of the frequency of the risk group and the frequency of the disease.
	5.	Meeting report Towards the integration of genomics, epidemiological and clinical data Victor V Solovyev, Tatiana V Tatarinova Genome Medicine 2011, 3:48 (27 July 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Victor Solovyev and Tatiana Tatarinova present the highlights and applications of new technologies of the Wellcome Trust Scientific Conference on 'Applied Bioinformatics and Public Health Microbiology 2011'.
	6.	Meeting report Exploring genomic studies in Africa Scott M Williams, Sarah A Tishkoff Genome Medicine 2011, 3:45 (8 July 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sarah Tishkoff and Scott Williams report on highlights from the African Society of Human Genetics meeting on 'Building Capacity for Genomic and Translational Research in Africa'.
	7.	Research *Genetic variants in the MRPS30* region and postmenopausal breast cancer risk** Ying Huang, Dennis G Ballinger, James Y Dai, Ulrike Peters, David A Hinds, David R Cox, Erica Beilharz, Rowan T Chlebowski, Jacques E Rossouw, Anne McTiernan, Thomas Rohan, Ross L Prentice Genome Medicine 2011, 3:42 (24 June 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Inclusion of hormonal and dietary exposure information links the MRPS30 genomic region to postmenopausal breast cancer risk, showing the importance of genotype by environment interactions.
	8.	Research *The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease* Carmen Antúnez, Mercè Boada, Antonio González-Pérez, Javier Gayán, Reposo Ramírez-Lorca, Juan Marín, Isabel Hernández, Concha Moreno-Rey, Francisco Morón, Jesús López-Arrieta, Ana Mauleón, Maitée Rosende-Roca, Fuensanta Noguera-Perea, Agustina Legaz-García, Laura Vivancos-Moreau, Juan Velasco, José Carrasco, Montserrat Alegret, Martirio Antequera-Torres, Salvadora Manzanares, Alejandro Romo, Irene Blanca, Susana Ruiz, Anna Espinosa, Sandra Castaño, Blanca García, Begoña Martínez-Herrada, Georgina Vinyes, Asunción Lafuente, James T Becker et al. Genome Medicine 2011, 3:33 (31 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A genome-wide association study in a Spanish population identifies a novel variant associated with Alzheimer’s disease, within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster.
	9.	Research highlight Testing for rare variant associations in complex diseases Jennifer Asimit, Eleftheria Zeggini Genome Medicine 2011, 3:24 (27 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Asimit and Zeggini highlight a new methodology developed by Ionita Laza et al. for detecting rare variants associated with a risk or protective effect in complex disease.
	10.	Research highlight Towards an understanding of genetic predisposition to migraine Verneri Anttila, Maija Wessman, Mikko Kallela, Aarno Palotie Genome Medicine 2011, 3:17 (21 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A recent genome-wide association study of migraine has linked it to a gene that regulates glutamate transporter gene expression, bridging the gap between Mendelian and common forms of this disorder.
	11.	Correspondence Strengthening the reporting of genetic risk prediction studies: the GRIPS statement A Cecile JW Janssens, John PA Ioannidis, Cornelia M van Duijn, Julian Little, Muin J Khoury, Genome Medicine 2011, 3:16 (15 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary With the recent increase in genetic risk prediction studies, a statement has been compiled to provide guidelines for the complete and accurate reporting of research methodology and findings.
	12.	Review The quest for genetic risk factors for Crohn's disease in the post-GWAS era Karin Fransen, Mitja Mitrovic, Cleo C van Diemen, Rinse K Weersma Genome Medicine 2011, 3:13 (25 February 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genome-wide association studies and meta-analyses have identified 71 risk loci so far, implicating roles for innate immunity, interleukin-23 receptor signaling and autophagy.
	13.	Editorial Genome Medicine: past, present and future Charles Auffray, Timothy Caulfield, Muin J Khoury, James R Lupski, Matthias Schwab, Timothy Veenstra Genome Medicine 2011, 3:6 (31 January 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary As Genome Medicine reaches its second anniversary, our Section Editors identify the most exciting recent breakthroughs and offer their opinions on what the future of genomic medicine might hold.
	14.	Commentary The clinical utility of testicular cancer risk loci Christian P Kratz, Gennady Bratslavsky, Jianxin Shi Genome Medicine 2011, 3:1 (21 January 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A predisposition to testicular germ cell tumors is highly heritable, but screening of the general population for associated genetic variants currently has no proven value.
	15.	Research Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data Joanne H Wang, Derek Pappas, Philip L De Jager, Daniel Pelletier, Paul IW de Bakker, Ludwig Kappos, Chris H Polman, Lori B Chibnik, David A Hafler, Paul M Matthews, Stephen L Hauser, Sergio E Baranzini, Jorge R Oksenberg Genome Medicine 2011, 3:3 (18 January 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A novel genetic profile for multiple sclerosis is enriched for genes involved in such pathways as immune response and nervous system development, providing insights into disease heterogeneity and genetic risk.