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Proteomic applications in medicine

Edited by: Sabine Bahn, Dr Paul Guest

Collection published: 27 February 2013

Last updated: 30 April 2013

The application of proteomic technologies to clinical specimens has the potential to revolutionize the treatment of many diseases. From biomarker discovery and validation to personalized therapies, proteomic techniques allow a greater understanding of the dynamic processes involved in disease, increasing the power of prediction, diagnosis and prognosis. Genome Medicine presents a series dedicated to proteomic applications in medicine, edited by Sabine Bahn and Paul Guest (University of Cambridge).

		Review Protein-protein interaction networks: probing disease mechanisms using model systems Uros Kuzmanov, Andrew Emili Genome Medicine 2013, 5:37 (30 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Kuzmanov and Emili review recent advances in protein-protein interaction studies from various model organisms, shedding light on the mechanisms and possible treatments for human disease.
		Review Proteomic profiling in schizophrenia: enabling stratification for more effective treatment Paul C Guest, Daniel Martins-de-Souza, Emanuel Schwarz, Hassan Rahmoune, Murtada Alsaif, Jakub Tomasik, Christoph W Turck, Sabine Bahn Genome Medicine 2013, 5:25 (26 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sabine Bahn and colleagues review the impact of studying co-morbidities and the use of proteomic profiling on the future of schizophrenia diagnosis and therapeutics.
		Meeting report Assessing biomarkers for brain diseases: progress and gaps Linda S Brady Genome Medicine 2013, 5:23 (20 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Linda Brady reports from the 2nd Wellcome Trust Scientific Conference on Biomarkers for Brain Disorders, highlighting recent progress and efforts to move biomarkers for these disorders into the clinic.
		Review Functional decorations: post-translational modifications and heart disease delineated by targeted proteomics Kiersten A Liddy, Melanie Y White, Stuart J Cordwell Genome Medicine 2013, 5:20 (28 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Liddy, White and Cordwell provide an overview of protein post-translational modifications, how they affect heart disease and how they can be analyzed by proteomics.
		Editorial Proteomics: improving biomarker translation to modern medicine? Paul C Guest, Michael G Gottschalk, Sabine Bahn Genome Medicine 2013, 5:17 (27 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Guest, Gottschalk and Bahn highlight the challenges and prospects for translational biomarker research in an Editorial introducing the "Proteomic applications in medicine" series.

		Review Protein-protein interaction networks: probing disease mechanisms using model systems Uros Kuzmanov, Andrew Emili Genome Medicine 2013, 5:37 (30 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Kuzmanov and Emili review recent advances in protein-protein interaction studies from various model organisms, shedding light on the mechanisms and possible treatments for human disease.
		Review Proteomic profiling in schizophrenia: enabling stratification for more effective treatment Paul C Guest, Daniel Martins-de-Souza, Emanuel Schwarz, Hassan Rahmoune, Murtada Alsaif, Jakub Tomasik, Christoph W Turck, Sabine Bahn Genome Medicine 2013, 5:25 (26 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sabine Bahn and colleagues review the impact of studying co-morbidities and the use of proteomic profiling on the future of schizophrenia diagnosis and therapeutics.
		Meeting report Assessing biomarkers for brain diseases: progress and gaps Linda S Brady Genome Medicine 2013, 5:23 (20 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Linda Brady reports from the 2nd Wellcome Trust Scientific Conference on Biomarkers for Brain Disorders, highlighting recent progress and efforts to move biomarkers for these disorders into the clinic.
		Review Functional decorations: post-translational modifications and heart disease delineated by targeted proteomics Kiersten A Liddy, Melanie Y White, Stuart J Cordwell Genome Medicine 2013, 5:20 (28 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Liddy, White and Cordwell provide an overview of protein post-translational modifications, how they affect heart disease and how they can be analyzed by proteomics.
		Editorial Proteomics: improving biomarker translation to modern medicine? Paul C Guest, Michael G Gottschalk, Sabine Bahn Genome Medicine 2013, 5:17 (27 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Guest, Gottschalk and Bahn highlight the challenges and prospects for translational biomarker research in an Editorial introducing the "Proteomic applications in medicine" series.