Genome Medicine | Article collections | Metabolomics of disease

Moving metabolomics from a data-driven science to an integrative systems science

Stacey N Reinke, David I Broadhurst Genome Medicine 2012, 4:85 (15 November 2012)

Abstract | Full text | PDF | PubMed | Editor’s summary

Stacey Reinke and David Broadhurst highlight recent developments from Metabomeeting 2012, held in Manchester, UK, from 25-27th September.

Serum metabolomic profile as a means to distinguish stage of colorectal cancer

Farshad Farshidfar, Aalim M Weljie, Karen Kopciuk, W Don Buie, Anthony MacLean, Elijah Dixon, Francis R Sutherland, Andrea Molckovsky, Hans J Vogel, Oliver F Bathe Genome Medicine 2012, 4:42 (14 May 2012)

Abstract | Full text | PDF | PubMed | Editor’s summary

Serum metabolomic profiles change markedly with metastasis of colorectal cancer, a finding that will have clinical utility in enhancing staging accuracy and selecting the right treatment for patients.

Metabolomics: the final frontier?

Timothy D Veenstra Genome Medicine 2012, 4:40 (30 April 2012)

Abstract | Full text | PDF | PubMed | Editor’s summary

Timothy Veenstra introduces Genome Medicine's special issue on metabolomics of disease, and discusses the impact and opportunities presented by metabolomics, the final piece of the omics puzzle.

Biomarker discovery in human cerebrospinal fluid: the need for integrative metabolome and proteome databases

Emanuel Schwarz, E Fuller Torrey, Paul C Guest, Sabine Bahn Genome Medicine 2012, 4:39 (30 April 2012)

Abstract | Full text | PDF | PubMed | Editor’s summary

Sabine Bahn and colleagues highlight an article in Genome Medicine that provides a comprehensive update to the CSF metabolome database, and discuss the need for an integrative metabolome-proteome database.

Multi-platform characterization of the human cerebrospinal fluid metabolome: a comprehensive and quantitative update

Rupasri Mandal, An Chi Guo, Kruti K Chaudhary, Philip Liu, Faizath S Yallou, Edison Dong, Farid Aziat, David S Wishart Genome Medicine 2012, 4:38 (30 April 2012)

A comprehensive and quantitative update of the human cerebrospinal fluid metabolome database is provided by multi-platform analysis of multiple CSF samples and an extensive literature review.

Metabolomics of human breast cancer: new approaches for tumor typing and biomarker discovery

Carsten Denkert, Elmar Bucher, Mika Hilvo, Reza Salek, Matej Orešič, Julian Griffin, Scarlet Brockmöller, Frederick Klauschen, Sibylle Loibl, Dinesh Barupal, Jan Budczies, Kristiina Iljin, Valentina Nekljudova, Oliver Fiehn Genome Medicine 2012, 4:37 (30 April 2012)

Abstract | Full text | PDF | PubMed | Editor’s summary

Denkert et al. review recent work showing that integrated metabolomic analyses can provide information on the stage, subtype and grade of breast tumors and give mechanistic insights into breast cancer.

Quantitative high-throughput metabolomics: a new era in epidemiology and genetics

Mika Ala-Korpela, Antti J Kangas, Pasi Soininen Genome Medicine 2012, 4:36 (30 April 2012)

Abstract | Full text | PDF | PubMed | Editor’s summary

Mika Ala-Korpela and colleagues advocate the use of multiple metabolomic markers to get a detailed, quantitative picture of disease etiology, particularly for complex diseases.

Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA)

Marta Ugarte, Marie Brown, Katherine A Hollywood, Garth J Cooper, Paul N Bishop, Warwick B Dunn Genome Medicine 2012, 4:35 (30 April 2012)

Metabolomic analysis of serum samples in a streptozotocin-induced diabetes rat model reveals metabolic pathways affected by treatment with oral triethylenetetramine, a potential therapy for diabetes.

Genome-wide association studies with metabolomics

Jerzy Adamski Genome Medicine 2012, 4:34 (30 April 2012)

Abstract | Full text | PDF | PubMed | Editor’s summary

Jerzy Adamski discusses the limitations of genome-wide association studies and presents examples of how metabolomics can overcome these limitations, focusing on metabolic diseases.

Cancer detection and biopsy classification using concurrent histopathological and metabolomic analysis of core biopsies

Meredith V Brown, Jonathan E McDunn, Philip R Gunst, Elizabeth M Smith, Michael V Milburn, Dean A Troyer, Kay A Lawton Genome Medicine 2012, 4:33 (30 April 2012)

Abstract | Full text | PDF | PubMed | Editor’s summary

A clinical workflow for concurrent metabolite extraction and histological analysis of intact tumor biopsies allows augmentation of histopathological diagnosis with quantitative biochemical measures.

Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancer

Zsuzsanna Ament, Mojgan Masoodi, Julian L Griffin Genome Medicine 2012, 4:32 (30 April 2012)

Julian Griffin and colleagues review the role metabolomics has played in elucidating the roles of peroxisome proliferator-activated receptors in systemic metabolism regulation.

Concentration of endogenous estrogens and estrogen metabolites in the NCI-60 human tumor cell lines

Xia Xu, Timothy D Veenstra Genome Medicine 2012, 4:31 (30 April 2012)

Abstract | Full text | PDF | PubMed | Editor’s summary

Systematic analysis of estrogen metabolite levels in NCI-60 human tumor cell lines reveals significant elevation of metabolites in cancers that are not dependent on these steroid hormones.

Genetic determinants of metabolism in health and disease: from biochemical genetics to genome-wide associations

Steven L Robinette, Elaine Holmes, Jeremy K Nicholson, Marc E Dumas Genome Medicine 2012, 4:30 (30 April 2012)

Robinette, Holmes, Nicholson and Dumas review data-fusion techniques using metabonomics, metabolomics and genomics, and the implications for functional genomics, metagenomics and disease modeling.

Differential effects of dietary supplements on metabolomic profile of smokers versus non-smokers

Robert C Spitale, Michelle Y Cheng, Kimberly A Chun, Emily S Gorell, Claudia A Munoz, Dale G Kern, Steve M Wood, Helen E Knaggs, Jacob Wulff, Kirk D Beebe, Anne Lynn S Chang Genome Medicine 2012, 4:14 (23 February 2012)

Abstract | Full text | PDF | PubMed | Editor’s summary

A study of the effects of antioxidant dietary supplementation on the metabolomes and the skin of smokers and non-smokers suggests that antioxidants may be of more benefit to smokers.

Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia

Matej Orešič, Tuulikki Seppänen-Laakso, Daqiang Sun, Jing Tang, Sebastian Therman, Rachael Viehman, Ulla Mustonen, Theo G van Erp, Tuulia Hyötyläinen, Paul Thompson, Arthur W Toga, Matti O Huttunen, Jaana Suvisaari, Jaakko Kaprio, Jouko Lönnqvist, Tyrone D Cannon Genome Medicine 2012, 4:1 (18 January 2012)

Abstract | Full text | PDF | PubMed | Editor’s summary

Lipidomic, imaging and neurocognitive analysis of twin pairs reveals lipid biomarkers linked to decreased cognitive speed and potentially increased susceptibility to infection in schizophrenia.

		Meeting report Moving metabolomics from a data-driven science to an integrative systems science Stacey N Reinke, David I Broadhurst Genome Medicine 2012, 4:85 (15 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Stacey Reinke and David Broadhurst highlight recent developments from Metabomeeting 2012, held in Manchester, UK, from 25-27th September.
		Research Serum metabolomic profile as a means to distinguish stage of colorectal cancer Farshad Farshidfar, Aalim M Weljie, Karen Kopciuk, W Don Buie, Anthony MacLean, Elijah Dixon, Francis R Sutherland, Andrea Molckovsky, Hans J Vogel, Oliver F Bathe Genome Medicine 2012, 4:42 (14 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Serum metabolomic profiles change markedly with metastasis of colorectal cancer, a finding that will have clinical utility in enhancing staging accuracy and selecting the right treatment for patients.
		Editorial Metabolomics: the final frontier? Timothy D Veenstra Genome Medicine 2012, 4:40 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Timothy Veenstra introduces Genome Medicine's special issue on metabolomics of disease, and discusses the impact and opportunities presented by metabolomics, the final piece of the omics puzzle.
		Research highlight Biomarker discovery in human cerebrospinal fluid: the need for integrative metabolome and proteome databases Emanuel Schwarz, E Fuller Torrey, Paul C Guest, Sabine Bahn Genome Medicine 2012, 4:39 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sabine Bahn and colleagues highlight an article in Genome Medicine that provides a comprehensive update to the CSF metabolome database, and discuss the need for an integrative metabolome-proteome database.
		Research Multi-platform characterization of the human cerebrospinal fluid metabolome: a comprehensive and quantitative update Rupasri Mandal, An Chi Guo, Kruti K Chaudhary, Philip Liu, Faizath S Yallou, Edison Dong, Farid Aziat, David S Wishart Genome Medicine 2012, 4:38 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary A comprehensive and quantitative update of the human cerebrospinal fluid metabolome database is provided by multi-platform analysis of multiple CSF samples and an extensive literature review.
		Review Metabolomics of human breast cancer: new approaches for tumor typing and biomarker discovery Carsten Denkert, Elmar Bucher, Mika Hilvo, Reza Salek, Matej Orešič, Julian Griffin, Scarlet Brockmöller, Frederick Klauschen, Sibylle Loibl, Dinesh Barupal, Jan Budczies, Kristiina Iljin, Valentina Nekljudova, Oliver Fiehn Genome Medicine 2012, 4:37 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Denkert et al. review recent work showing that integrated metabolomic analyses can provide information on the stage, subtype and grade of breast tumors and give mechanistic insights into breast cancer.
		Musings Quantitative high-throughput metabolomics: a new era in epidemiology and genetics Mika Ala-Korpela, Antti J Kangas, Pasi Soininen Genome Medicine 2012, 4:36 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mika Ala-Korpela and colleagues advocate the use of multiple metabolomic markers to get a detailed, quantitative picture of disease etiology, particularly for complex diseases.
		Research Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA) Marta Ugarte, Marie Brown, Katherine A Hollywood, Garth J Cooper, Paul N Bishop, Warwick B Dunn Genome Medicine 2012, 4:35 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Metabolomic analysis of serum samples in a streptozotocin-induced diabetes rat model reveals metabolic pathways affected by treatment with oral triethylenetetramine, a potential therapy for diabetes.
		Review Genome-wide association studies with metabolomics Jerzy Adamski Genome Medicine 2012, 4:34 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jerzy Adamski discusses the limitations of genome-wide association studies and presents examples of how metabolomics can overcome these limitations, focusing on metabolic diseases.
		Research Cancer detection and biopsy classification using concurrent histopathological and metabolomic analysis of core biopsies Meredith V Brown, Jonathan E McDunn, Philip R Gunst, Elizabeth M Smith, Michael V Milburn, Dean A Troyer, Kay A Lawton Genome Medicine 2012, 4:33 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A clinical workflow for concurrent metabolite extraction and histological analysis of intact tumor biopsies allows augmentation of histopathological diagnosis with quantitative biochemical measures.
		Review Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancer Zsuzsanna Ament, Mojgan Masoodi, Julian L Griffin Genome Medicine 2012, 4:32 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Julian Griffin and colleagues review the role metabolomics has played in elucidating the roles of peroxisome proliferator-activated receptors in systemic metabolism regulation.
		Research Concentration of endogenous estrogens and estrogen metabolites in the NCI-60 human tumor cell lines Xia Xu, Timothy D Veenstra Genome Medicine 2012, 4:31 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Systematic analysis of estrogen metabolite levels in NCI-60 human tumor cell lines reveals significant elevation of metabolites in cancers that are not dependent on these steroid hormones.
		Review Genetic determinants of metabolism in health and disease: from biochemical genetics to genome-wide associations Steven L Robinette, Elaine Holmes, Jeremy K Nicholson, Marc E Dumas Genome Medicine 2012, 4:30 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Robinette, Holmes, Nicholson and Dumas review data-fusion techniques using metabonomics, metabolomics and genomics, and the implications for functional genomics, metagenomics and disease modeling.
		Research Differential effects of dietary supplements on metabolomic profile of smokers versus non-smokers Robert C Spitale, Michelle Y Cheng, Kimberly A Chun, Emily S Gorell, Claudia A Munoz, Dale G Kern, Steve M Wood, Helen E Knaggs, Jacob Wulff, Kirk D Beebe, Anne Lynn S Chang Genome Medicine 2012, 4:14 (23 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A study of the effects of antioxidant dietary supplementation on the metabolomes and the skin of smokers and non-smokers suggests that antioxidants may be of more benefit to smokers.
		Research Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia Matej Orešič, Tuulikki Seppänen-Laakso, Daqiang Sun, Jing Tang, Sebastian Therman, Rachael Viehman, Ulla Mustonen, Theo G van Erp, Tuulia Hyötyläinen, Paul Thompson, Arthur W Toga, Matti O Huttunen, Jaana Suvisaari, Jaakko Kaprio, Jouko Lönnqvist, Tyrone D Cannon Genome Medicine 2012, 4:1 (18 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Lipidomic, imaging and neurocognitive analysis of twin pairs reveals lipid biomarkers linked to decreased cognitive speed and potentially increased susceptibility to infection in schizophrenia.

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Metabolomics of disease