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	1. 8728 Accesses	Review Gut microbiome-host interactions in health and disease James M Kinross, Ara W Darzi, Jeremy K Nicholson Genome Medicine 2011, 3:14 (4 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The gut microbiome plays an important role in human disease and further understanding microbiome activity is crucial for the development of future personalized treatment strategies.
	2. 7888 Accesses	Review Future medical applications of single-cell sequencing in cancer Nicholas Navin, James Hicks Genome Medicine 2011, 3:31 (31 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Navin and Hicks provide an overview of recent methods for sequencing in single cells and discuss how this approach will be useful for detection of copy number variation for improving cancer outcomes.
	3. 5969 Accesses	Review Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease Alvaro Rada-Iglesias, Joanna Wysocka Genome Medicine 2011, 3:36 (7 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Wysocka and Rada-Iglesias review advances in epigenomic profiling of human pluripotent stem cells, highlighting the roles of regulatory elements and the implications for disease.
	4. 5312 Accesses	Correspondence Systems medicine and integrated care to combat chronic noncommunicable diseases Jean Bousquet, Josep M Anto, Peter J Sterk, Ian M Adcock, Kian Chung, Josep Roca, Alvar Agusti, Chris Brightling, Anne Cambon-Thomsen, Alfredo Cesario, Sonia Abdelhak, Stylianos E Antonarakis, Antoine Avignon, Andrea Ballabio, Eugenio Baraldi, Alexander Baranov, Thomas Bieber, Joël Bockaert, Samir Brahmachari, Christian Brambilla, Jacques Bringer, Michel Dauzat, Ingemar Ernberg, Leonardo Fabbri, Philippe Froguel, David Galas, Takashi Gojobori, Peter Hunter, Christian Jorgensen, Francine Kauffmann et al. Genome Medicine 2011, 3:43 (6 July 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A holistic and patient-centered strategy for tackling non-communicable diseases is proposed, based on the principles of predictive, preventive, personalized and participatory (P4) medicine.
	5. 4766 Accesses	Review Stem cell approaches for diabetes: towards beta cell replacement Gordon C Weir, Claudia Cavelti-Weder, Susan Bonner-Weir Genome Medicine 2011, 3:61 (27 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gordon Weir at al. review advances in understanding diabetes at the genomic level, and discuss how stem-cell-based approaches might be used for replacing beta cells and for treating the various forms of diabetes.
	6. 4594 Accesses	Correspondence Towards a data sharing Code of Conduct for international genomic research Bartha Knoppers, Jennifer R Harris, Anne Tassé, Isabelle Budin-Ljøsne, Jane Kaye, Mylène Deschênes, Ma'n H Zawati Genome Medicine 2011, 3:46 (14 July 2011) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| F1000 Biology \| Editor’s summary An international code of conduct for sharing genomic data is proposed, incorporating seven principles: quality, accessibility, responsibility, security, transparency, accountability and integrity.
	7. 4422 Accesses	Review Systems medicine: the future of medical genomics and healthcare Charles Auffray, Zhu Chen, Leroy Hood Genome Med 2009, 1:2 (20 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Systems approaches to medicine will transform the way drugs are developed and will enable medicine to become predictive, personalized, preventive and participatory.
	8. 4255 Accesses	Research Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort Katherine R Smith, Vijayaprakash Suppiah, Kate O'Connor, Thomas Berg, Martin Weltman, Maria Abate, Ulrich Spengler, Margaret Bassendine, Gail Matthews, William L Irving, Elizabeth Powell, Stephen Riordan, Golo Ahlenstiel, Graeme J Stewart, Melanie Bahlo, Jacob George, David R Booth, the International Hepatitis C Genetics Consortium (IHCGC) Genome Medicine 2011, 3:57 (31 August 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Novel variants in the IL28B gene region, which predict lack of response to conventional treatment of hepatitis C virus, are identified through massively parallel sequencing using pooled DNA.
	9. 4182 Accesses	Research Metabolome in schizophrenia and other psychotic disorders: a general population-based study Matej Orešič, Jing Tang, Tuulikki Seppänen-Laakso, Ismo Mattila, Suoma E Saarni, Samuli I Saarni, Jouko Lönnqvist, Marko Sysi-Aho, Tuulia Hyötyläinen, Jonna Perälä, Jaana Suvisaari Genome Medicine 2011, 3:19 (23 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A population-based metabolomics study in Finland reveals disease-specific metabolic abnormalities associated with schizophrenia, compared with other psychotic disorders.
	10. 4146 Accesses	Research Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks Aaron M Newman, Natasha B Gallo, Lisa S Hancox, Norma J Miller, Carolyn M Radeke, Michelle A Maloney, James B Cooper, Gregory S Hageman, Don H Anderson, Lincoln V Johnson, Monte J Radeke Genome Medicine 2012, 4:16 (24 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Comparative transcriptome profiling of eye specimens, integrated with functionally enriched protein network analysis reveals candidate drug targets for treating age-related macular degeneration.
	11. 3941 Accesses	Research Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme Kristian Ovaska, Marko Laakso, Saija Haapa-Paananen, Riku Louhimo, Ping Chen, Viljami Aittomäki, Erkka Valo, Javier Núñez-Fontarnau, Ville Rantanen, Sirkku Karinen, Kari Nousiainen, Anna-Maria Lahesmaa-Korpinen, Minna Miettinen, Lilli Saarinen, Pekka Kohonen, Jianmin Wu, Jukka Westermarck, Sampsa Hautaniemi Genome Medicine 2010, 2:65 (7 September 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Anduril, a computational framework that allows for rapid integration of heterogeneous molecular and clinical information, identifies Moesin as a novel gene associated with survival in glioblastoma multiforme and represents a valuable tool for systems analyses.
	12. 3919 Accesses	Review Biomarkers in solid organ transplantation: establishing personalized transplantation medicine Silke Roedder, Matthew Vitalone, Purvesh Khatri, Minnie M Sarwal Genome Medicine 2011, 3:37 (8 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Minnie Sarwal and colleagues review the rocky road to regulatory approval in the search for biomarkers for organ transplants that will help predict the chances of success and increase graft survival.
	13. 3911 Accesses	Research The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease Carmen Antúnez, Mercè Boada, Antonio González-Pérez, Javier Gayán, Reposo Ramírez-Lorca, Juan Marín, Isabel Hernández, Concha Moreno-Rey, Francisco Morón, Jesús López-Arrieta, Ana Mauleón, Maitée Rosende-Roca, Fuensanta Noguera-Perea, Agustina Legaz-García, Laura Vivancos-Moreau, Juan Velasco, José Carrasco, Montserrat Alegret, Martirio Antequera-Torres, Salvadora Manzanares, Alejandro Romo, Irene Blanca, Susana Ruiz, Anna Espinosa, Sandra Castaño, Blanca García, Begoña Martínez-Herrada, Georgina Vinyes, Asunción Lafuente, James T Becker et al. Genome Medicine 2011, 3:33 (31 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A genome-wide association study in a Spanish population identifies a novel variant associated with Alzheimer’s disease, within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster.
	14. 3907 Accesses	Review Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine Jonghwan Kim, Stuart H Orkin Genome Medicine 2011, 3:75 (29 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jonghwan Kim and Stuart Orkin review recent genome-scale and systems approaches to understand the regulatory networks that are common to embryonic stem (ES) cells and cancer.
	15. 3790 Accesses	Research Pharmacogenetic testing affects choice of therapy among women considering tamoxifen treatment Wendy Lorizio, Hope Rugo, Mary S Beattie, Simone Tchu, Teri Melese, Michelle Melisko, Alan HB Wu, H Jeffrey Lawrence, Michele Nikoloff, Elad Ziv Genome Medicine 2011, 3:64 (4 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The choice of medication for breast cancer patients was changed after CYP2D6 genotyping, demonstrating for the first time that pharmacogenetics can shape clinical treatment decisions.
	16. 3761 Accesses	Review Capturing Alzheimer's disease genomes with induced pluripotent stem cells: prospects and challenges Mason A Israel, Lawrence SB Goldstein Genome Medicine 2011, 3:49 (27 July 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mason Israel and Lawrence Goldstein review the prospects and challenges for studying Alzheimer's disease genes and modeling pathogenesis using patient-derived induced pluripotent stem cells (iPSCs).
	17. 3709 Accesses	Musings The $1,000 genome, the $100,000 analysis? Elaine R Mardis Genome Medicine 2010, 2:84 (26 November 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Lowered price and speed brings routine clinical use of whole-genome sequencing ever closer, but improved reference and functional data and dedicated analysis pipelines are required to make it a reality.
	18. 3607 Accesses	Research Predictive genetic testing for the identification of high-risk groups: a simulation study on the impact of predictive ability Raluca Mihaescu, Ramal Moonesinghe, Muin J Khoury, A Janssens Genome Medicine 2011, 3:51 (28 July 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Analysis of the predictive ability of risk models to identify high-risk groups for complex diseases highlights the importance of the frequency of the risk group and the frequency of the disease.
	19. 3596 Accesses	Editorial Genome Medicine: past, present and future Charles Auffray, Timothy Caulfield, Muin J Khoury, James R Lupski, Matthias Schwab, Timothy Veenstra Genome Medicine 2011, 3:6 (31 January 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary As Genome Medicine reaches its second anniversary, our Section Editors identify the most exciting recent breakthroughs and offer their opinions on what the future of genomic medicine might hold.
	20. 3530 Accesses	Review Gene expression and hypoxia in breast cancer Elena Favaro, Simon Lord, Adrian L Harris, Francesca M Buffa Genome Medicine 2011, 3:55 (26 August 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Francesca Buffa, Adrian Harris and colleagues review gene and microRNA expression signatures for tumor-associated hypoxia and their potential for diagnosis and treatment of breast cancer.
	21. 3510 Accesses	Research Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival Anita Sveen, Trude H Ågesen, Arild Nesbakken, Torleiv O Rognum, Ragnhild A Lothe, Rolf I Skotheim Genome Medicine 2011, 3:32 (27 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Exon microarray analyses of colorectal cancer tissues reveal different relative levels of transcriptome instability with associations with splicing factor expression and patient prognosis.
	22. 3471 Accesses	Editorial Genome Medicine: stem cells, genomics and translational research Stuart H Orkin Genome Medicine 2011, 3:34 (7 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An editorial by Guest Editor Stuart Orkin introduces this new series of articles, highlighting progress in genomic-scale studies of stem cells and cellular reprogramming that could impact medicine.
	23. 3611 Accesses	Editorial Metabolomics: the final frontier? Timothy D Veenstra Genome Medicine 2012, 4:40 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Timothy Veenstra introduces Genome Medicine's special issue on metabolomics of disease, and discusses the impact and opportunities presented by metabolomics, the final piece of the omics puzzle.
	24. 3296 Accesses	Review Methods for the de-identification of electronic health records for genomic research Khaled El Emam Genome Medicine 2011, 3:25 (27 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary As electronic health records are increasingly used in research, Khaled El Emam reviews the need for effective de-identification methods to reduce the risk of re-identification for disclosed data.
	25. 3252 Accesses	Review Genetic overlap between autism, schizophrenia and bipolar disorder Liam S Carroll, Michael J Owen Genome Medicine 2009, 1:102 (30 October 2009) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Overlap between the loci that predispose to autism, schizophrenia and bipolar disorder suggests shared pathogenic mechanisms and challenges the view that these disorders are unrelated diagnostic entities.