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	1.	Research Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia Matej Oresic, Tuulikki Seppanen-Laakso, Daqiang Sun, Jing Tang, Sebastian Therman, Rachael Viehman, Ulla Mustonen, Theo GM van Erp, Tuulia Hyotylainen, Paul Thompson, Arthur W Toga, Matti O Huttunen, Jaana Suvisaari, Jaakko Kaprio, Jouko Lonnqvist, Tyrone D Cannon Genome Medicine 2012, 4:1 (18 January 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Lipidomic, imaging and neurocognitive analysis of twin pairs reveals lipid biomarkers linked to decreased cognitive speed and potentially increased susceptibility to infection in schizophrenia.
	2.	Editorial Looking back at genomic medicine in 2011 Charles Auffray, Timothy Caulfield, Muin J Khoury, James R Lupski, Matthias Schwab, Timothy Veenstra Genome Medicine 2012, 4:9 (30 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An editorial by our Section Editors provides their highlights of the past year and hints at likely future developments in genomic medicine.
	3.	Review Gut microbiome-host interactions in health and disease James M Kinross, Ara W Darzi, Jeremy K Nicholson Genome Medicine 2011, 3:14 (4 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The gut microbiome plays an important role in human disease and further understanding microbiome activity is crucial for the development of future personalized treatment strategies.
	4.	Review Emerging patterns of genetic overlap across autoimmune disorders Corinne Richard-Miceli, Lindsey A Criswell Genome Medicine 2012, 4:6 (27 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Lindsey Criswell and Corinne Richard-Miceli review risk loci that are shared among autoimmune disorders and how this information might help to explain common disease mechanisms.
	5.	Research The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls Marcus Ronninger, Yongjing Guo, Klementy Shchetynsky, Andrew Hill, Mohsen Khademi, Tomas Olsson, Padmalatha S Reddy, Maria Seddighzadeh, James D Clark, Lih-Ling Lin, Margot O'Toole, Leonid Padyukov Genome Medicine 2012, 4:2 (20 January 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Genotyping and phenotyping of cells from rheumatoid arthritis patients and healthy controls reveals different patterns of expression for the protein tyrosine phosphatase non-receptor 22 gene.
	6.	Research highlight Improving bioinformatic pipelines for exome variant calling Hanlee P Ji Genome Medicine 2012, 4:7 (30 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hanlee Ji discusses the Atlas2 suite, a new set of tools for calling variants in exome sequencing data that is faster and easier to use than comparable tools and could thus be useful in diagnostics.
	7.	Review Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine Jonghwan Kim, Stuart H Orkin Genome Medicine 2011, 3:75 (29 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jonghwan Kim and Stuart Orkin review recent genome-scale and systems approaches to understand the regulatory networks that are common to embryonic stem (ES) cells and cancer.
	8.	Review Future medical applications of single-cell sequencing in cancer Nicholas Navin, James Hicks Genome Medicine 2011, 3:31 (31 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Navin and Hicks provide an overview of recent methods for sequencing in single cells and discuss how this approach will be useful for detection of copy number variation for improving cancer outcomes.
	9.	Review Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model Corey S Martin, Akemi Moriyama, Leonard I Zon Genome Medicine 2011, 3:83 (29 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Martin, Moriyama and Zon review the advantages of zebrafish for studying early development of blood cells and highlight recent discoveries using this model that show clinical promise.
	10.	Opinion From hepatitis to hepatocellular carcinoma: a proposed model for cross-talk between inflammation and epigenetic mechanisms Marion Martin, Zdenko Herceg Genome Medicine 2012, 4:8 (31 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Marion Martin and Zdenko Herceg discuss how cross-talk between inflammation and epigenetic mechanisms might be involved in the development of liver cancer.
	11.	Meeting report Pharmacogenomics and personalized medicine: the plunge into next-generation sequencing Mia Wadelius, Ana Alfirevic Genome Medicine 2011, 3:78 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mia Wadelius and Ana Alfirevic present highlights from the Cold Spring Harbor and the Wellcome Trust 2011 meeting on 'Pharmacogenomics and Personalized Medicine'.
	12.	Review Stem cell approaches for diabetes: towards beta cell replacement Gordon C Weir, Claudia Cavelti-Weder, Susan Bonner-Weir Genome Medicine 2011, 3:61 (27 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gordon Weir at al. review advances in understanding diabetes at the genomic level, and discuss how stem-cell-based approaches might be used for replacing beta cells and for treating the various forms of diabetes.
	13.	Research DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma Elke Schaeffeler, Claus Hellerbrand, Anne T Nies, Stefan Winter, Stephan Kruck, Ute Hofmann, Heiko van der Kuip, Ulrich M Zanger, Hermann Koepsell, Matthias Schwab Genome Medicine 2011, 3:82 (23 December 2011) Abstract \| Provisional PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary First evidence that decreased protein expression of the transporter SLC22A1 in hepatocellular carcinoma correlates with increased methylation of individual CpG sites.
	14.	Research highlight Predicting responses to sunitinib using single nucleotide polymorphisms: Progress and recommendations for future trials Ram N Ganapathi, Ronald M Bukowski Genome Medicine 2011, 3:79 (30 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ganapathi and Bukowski discuss the advances and pitfalls of a recent study of single nucleotide polymorphisms to predict the activity or toxicity of sunitinib for clear cell renal cell carcinoma.
	15.	Meeting report A year of great leaps in genome research Jingde Zhu Genome Medicine 2012, 4:4 (30 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jingde Zhu presents the recent progress made and highlights of the Beijing Genomics Institute's 6th International Conference on Genomics (ICG-VI), held in Shenzhen, China.
	16.	Review Pharmacogenetics in type 2 diabetes: potential implications for clinical practice Chunmei Huang, Jose C Florez Genome Medicine 2011, 3:76 (29 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Chunmei Huang and Jose Florez review recent insights into type 2 diabetes that are emerging from pharmacogenetic and pharmacogenomic studies, and discuss the potential for clinical translation.
	17.	Review Health care providers and direct-to-consumer access and advertising of genetic testing in the United States Melanie F Myers Genome Medicine 2011, 3:81 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Melanie Myers reviews the impact of advertising and selling of genetic testing direct to consumers on health care providers and asks whether providers are ready to deal with this issue.
	18.	Review Systems medicine: the future of medical genomics and healthcare Charles Auffray, Zhu Chen, Leroy Hood Genome Med 2009, 1:2 (20 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Systems approaches to medicine will transform the way drugs are developed and will enable medicine to become predictive, personalized, preventive and participatory.
	19.	Research Metabolome in schizophrenia and other psychotic disorders: a general population-based study Matej Orešič, Jing Tang, Tuulikki Seppänen-Laakso, Ismo Mattila, Suoma E Saarni, Samuli I Saarni, Jouko Lönnqvist, Marko Sysi-Aho, Tuulia Hyötyläinen, Jonna Perälä, Jaana Suvisaari Genome Medicine 2011, 3:19 (23 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A population-based metabolomics study in Finland reveals disease-specific metabolic abnormalities associated with schizophrenia, compared with other psychotic disorders.
	20.	Research highlight Recycling side-effects into clinical markers for drug repositioning Miquel Duran-Frigola, Patrick Aloy Genome Medicine 2012, 4:3 (27 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Miquel Duran-Frigola and Patrick Aloy discuss a new computational approach to systematically exploring novel potential applications of already marketed drugs in distinct therapeutic areas.
	21.	Review Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease Alvaro Rada-Iglesias, Joanna Wysocka Genome Medicine 2011, 3:36 (7 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Wysocka and Rada-Iglesias review advances in epigenomic profiling of human pluripotent stem cells, highlighting the roles of regulatory elements and the implications for disease.
	22.	Meeting report The long journey of stem cell therapeutics Sarah Crawford Genome Medicine 2012, 4:5 (27 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sarah Crawford presents the highlights and roadblocks of therapeutic applications from the Euroepistem 2011 meeting on 'Epigenomic Programming and Stem Cells for Drug Discovery'.
	23.	Review Capturing Alzheimer's disease genomes with induced pluripotent stem cells: prospects and challenges Mason A Israel, Lawrence SB Goldstein Genome Medicine 2011, 3:49 (27 July 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mason Israel and Lawrence Goldstein review the prospects and challenges for studying Alzheimer's disease genes and modeling pathogenesis using patient-derived induced pluripotent stem cells (iPSCs).
	24.	Musings The $1,000 genome, the $100,000 analysis? Elaine R Mardis Genome Medicine 2010, 2:84 (26 November 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Lowered price and speed brings routine clinical use of whole-genome sequencing ever closer, but improved reference and functional data and dedicated analysis pipelines are required to make it a reality.
	25.	Review Transcriptomic analysis of pluripotent stem cells: insights into health and disease Jia-Chi Yeo, Huck-Hui Ng Genome Medicine 2011, 3:68 (27 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jia-Chi Yeo and Huck-Hui Ng review recent progress in understanding the transcriptional networks of pluripotent stem cells, and discuss how this knowledge has impacted translational medicine.