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	1. 3611 Accesses	Editorial Metabolomics: the final frontier? Timothy D Veenstra Genome Medicine 2012, 4:40 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Timothy Veenstra introduces Genome Medicine's special issue on metabolomics of disease, and discusses the impact and opportunities presented by metabolomics, the final piece of the omics puzzle.
	2. 1728 Accesses	Research Gene regulatory network inference: evaluation and application to ovarian cancer allows the prioritization of drug targets Piyush B Madhamshettiwar, Stefan R Maetschke, Melissa J Davis, Antonio Reverter, Mark A Ragan Genome Medicine 2012, 4:41 (1 May 2012) Abstract \| Provisional PDF \| PubMed
	3. 1699 Accesses	Review Genome-wide association studies with metabolomics Jerzy Adamski Genome Medicine 2012, 4:34 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jerzy Adamski discusses the limitations of genome-wide association studies and presents examples of how metabolomics can overcome these limitations, focusing on metabolic diseases.
	4. 1640 Accesses	Review Genetic determinants of metabolism in health and disease: from biochemical genetics to genome-wide associations Steven L Robinette, Elaine Holmes, Jeremy K Nicholson, Marc E Dumas Genome Medicine 2012, 4:30 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Robinette, Holmes, Nicholson and Dumas review data-fusion techniques using metabonomics, metabolomics and genomics, and the implications for functional genomics, metagenomics and disease modeling.
	5. 1452 Accesses	Review Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancer Zsuzsanna Ament, Mojgan Masoodi, Julian L Griffin Genome Medicine 2012, 4:32 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Julian Griffin and colleagues review the role metabolomics has played in elucidating the roles of peroxisome proliferator-activated receptors in systemic metabolism regulation.
	6. 1426 Accesses	Review Metabolomics of human breast cancer: new approaches for tumor typing and biomarker discovery Carsten Denkert, Elmar Bucher, Mika Hilvo, Reza Salek, Matej Orešič, Julian Griffin, Scarlet Brockmöller, Frederick Klauschen, Sibylle Loibl, Dinesh Barupal, Jan Budczies, Kristiina Iljin, Valentina Nekljudova, Oliver Fiehn Genome Medicine 2012, 4:37 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Denkert et al. review recent work showing that integrated metabolomic analyses can provide information on the stage, subtype and grade of breast tumors and give mechanistic insights into breast cancer.
	7. 1212 Accesses	Musings Quantitative high-throughput metabolomics: a new era in epidemiology and genetics Mika Ala-Korpela, Antti J Kangas, Pasi Soininen Genome Medicine 2012, 4:36 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mika Ala-Korpela and colleagues advocate the use of multiple metabolomic markers to get a detailed, quantitative picture of disease etiology, particularly for complex diseases.
	8. 892 Accesses	Research highlight Biomarker discovery in human cerebrospinal fluid: the need for integrative metabolome and proteome databases Emanuel Schwarz, E Fuller Torrey, Paul C Guest, Sabine Bahn Genome Medicine 2012, 4:39 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sabine Bahn and colleagues highlight an article in Genome Medicine that provides a comprehensive update to the CSF metabolome database, and discuss the need for an integrative metabolome-proteome database.
	9. 822 Accesses	Research Multi-platform characterization of the human cerebrospinal fluid metabolome: a comprehensive and quantitative update Rupasri Mandal, An Chi Guo, Kruti K Chaudhary, Philip Liu, Faizath S Yallou, Edison Dong, Farid Aziat, David S Wishart Genome Medicine 2012, 4:38 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A comprehensive and quantitative update of the human cerebrospinal fluid metabolome database is provided by multi-platform analysis of multiple CSF samples and an extensive literature review.
	10. 760 Accesses	Research Cancer detection and biopsy classification using concurrent histopathological and metabolomic analysis of core biopsies Meredith V Brown, Jonathan E McDunn, Phillip R Gunst, Elizabeth M Smith, Michael V Milburn, Dean A Troyer, Kay A Lawton Genome Medicine 2012, 4:33 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A clinical workflow for concurrent metabolite extraction and histological analysis of intact tumor biopsies allows augmentation of histopathological diagnosis with quantitative biochemical measures.
	11. 696 Accesses	Review Gut microbiome-host interactions in health and disease James M Kinross, Ara W Darzi, Jeremy K Nicholson Genome Medicine 2011, 3:14 (4 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The gut microbiome plays an important role in human disease and further understanding microbiome activity is crucial for the development of future personalized treatment strategies.
	12. 678 Accesses	Research Serum metabolomic profile as a means to distinguish stage of colorectal cancer Farshad Farshidfar, Aalim M Weljie, Karen Kopciuk, W DON Buie, Anthony MacLean, Elijah Dixon, Francis R Sutherland, Andrea Molckovsky, Hans J Vogel, Oliver F Bathe Genome Medicine 2012, 4:42 (14 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Serum metabolomic profiles change markedly with metastasis of colorectal cancer, a finding that will have clinical utility in enhancing staging accuracy and selecting the right treatment for patients.
	13. 608 Accesses	Review Drug repositioning for personalized medicine Yvonne Y Li, Steven JM Jones Genome Medicine 2012, 4:27 (30 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Steven Jones and Yvonne Li review how drug discovery can be made more efficient by repositioning of approved drugs to treat new diseases and by identifying patients who will benefit from such treatments.
	14. 599 Accesses	Research Concentration of endogenous estrogens and estrogen metabolites in the NCI-60 human tumor cell lines Xia Xu, Timothy D Veenstra Genome Medicine 2012, 4:31 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Systematic analysis of estrogen metabolite levels in NCI-60 human tumor cell lines reveals significant elevation of metabolites in cancers that are not dependent on these steroid hormones.
	15. 584 Accesses	Review DNA methylation signatures for breast cancer classification and prognosis Moshe Szyf Genome Medicine 2012, 4:26 (30 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Moshe Szyf reviews recent progress in identifying DNA methylation in breast cancer genomes, and discusses the prospects for classifying subtypes and predicting outcome using DNA methylation markers.
	16. 580 Accesses	Research Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA) Marta Ugarte, Marie Brown, Katherine A Hollywood, Garth J Cooper, Paul N Bishop, Warwick B Dunn Genome Medicine 2012, 4:35 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Metabolomic analysis of serum samples in a streptozotocin-induced diabetes rat model reveals metabolic pathways affected by treatment with oral triethylenetetramine, a potential therapy for diabetes.
	17. 543 Accesses	Open debate Open science versus commercialization: a modern research conflict? Timothy Caulfield, Shawn HE Harmon, Yann Joly Genome Medicine 2012, 4:17 (27 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary University researchers, particularly in genomics, are being asked to both commercialize their research and to disseminate it quickly through an open science model. Are these instructions in conflict?
	18. 525 Accesses	Research Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation Andrew E Teschendorff, Allison Jones, Heidi Fiegl, Alexandra Sargent, Joanna J Zhuang, Henry C Kitchener, Martin Widschwendter Genome Medicine 2012, 4:24 (27 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Risk of neoplastic transformation can be predicted from DNA methylation profiles of morphologically normal uterine cervical cells, with potential future applications in clinical screening.
	19. 496 Accesses	Research Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks Aaron M Newman, Natasha B Gallo, Lisa S Hancox, Norma J Miller, Carolyn M Radeke, Michelle A Maloney, James B Cooper, Gregory S Hageman, Don H Anderson, Lincoln V Johnson, Monte J Radeke Genome Medicine 2012, 4:16 (24 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Comparative transcriptome profiling of eye specimens, integrated with functionally enriched protein network analysis reveals candidate drug targets for treating age-related macular degeneration.
	20. 461 Accesses	Review Future medical applications of single-cell sequencing in cancer Nicholas Navin, James Hicks Genome Medicine 2011, 3:31 (31 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Navin and Hicks provide an overview of recent methods for sequencing in single cells and discuss how this approach will be useful for detection of copy number variation for improving cancer outcomes.
	21. 432 Accesses	Research Differential effects of dietary supplements on metabolomic profile of smokers versus non-smokers Robert C Spitale, Michelle Y Cheng, Kimberly A Chun, Emily S Gorell, Claudia A Munoz, Dale G Kern, Steve M Wood, Helen E Knaggs, Jacob Wulff, Kirk D Beebe, Anne Lynn S Chang Genome Medicine 2012, 4:14 (23 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A study of the effects of antioxidant dietary supplementation on the metabolomes and the skin of smokers and non-smokers suggests that antioxidants may be of more benefit to smokers.
	22. 399 Accesses	Research Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes Iain J Gallagher, Camilla Scheele, Pernille Keller, Anders R Nielsen, Judit Remenyi, Christian P Fischer, Karim Roder, John Babraj, Claes Wahlestedt, Gyorgy Hutvagner, Bente K Pedersen, James A Timmons Genome Medicine 2010, 2:9 (1 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Muscle mRNA expression is invariant with respect to diabetes status, but coordinated changes in numerous microRNAs may control protein abundance and affect skeletal muscle insulin resistance, a critical component of the disease.
	23. 389 Accesses	Review Systems medicine: the future of medical genomics and healthcare Charles Auffray, Zhu Chen, Leroy Hood Genome Med 2009, 1:2 (20 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Systems approaches to medicine will transform the way drugs are developed and will enable medicine to become predictive, personalized, preventive and participatory.
	24. 381 Accesses	Review Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease Alvaro Rada-Iglesias, Joanna Wysocka Genome Medicine 2011, 3:36 (7 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Wysocka and Rada-Iglesias review advances in epigenomic profiling of human pluripotent stem cells, highlighting the roles of regulatory elements and the implications for disease.
	25. 381 Accesses	Review Stem cell approaches for diabetes: towards beta cell replacement Gordon C Weir, Claudia Cavelti-Weder, Susan Bonner-Weir Genome Medicine 2011, 3:61 (27 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gordon Weir at al. review advances in understanding diabetes at the genomic level, and discuss how stem-cell-based approaches might be used for replacing beta cells and for treating the various forms of diabetes.