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	1.	Research Pharmacogenetic testing affects choice of therapy among women considering tamoxifen treatment Wendy Lorizio, Hope Rugo, Mary S Beattie, Simone Tchu, Teri Melese, Michelle Melisko, Alan HB Wu, H Jeffrey Lawrence, Michele Nikoloff, Elad Ziv Genome Medicine 2011, 3:64 (4 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The choice of medication for breast cancer patients was changed after CYP2D6 genotyping, demonstrating for the first time that pharmacogenetics can shape clinical treatment decisions.
	2.	Research Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival Anita Sveen, Trude H Ågesen, Arild Nesbakken, Torleiv O Rognum, Ragnhild A Lothe, Rolf I Skotheim Genome Medicine 2011, 3:32 (27 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Exon microarray analyses of colorectal cancer tissues reveal different relative levels of transcriptome instability with associations with splicing factor expression and patient prognosis.
	3.	Correspondence Systems medicine and integrated care to combat chronic noncommunicable diseases Jean Bousquet, Josep M Anto, Peter J Sterk, Ian M Adcock, Kian Chung, Josep Roca, Alvar Agusti, Chris Brightling, Anne Cambon-Thomsen, Alfredo Cesario, Sonia Abdelhak, Stylianos E Antonarakis, Antoine Avignon, Andrea Ballabio, Eugenio Baraldi, Alexander Baranov, Thomas Bieber, Joël Bockaert, Samir Brahmachari, Christian Brambilla, Jacques Bringer, Michel Dauzat, Ingemar Ernberg, Leonardo Fabbri, Philippe Froguel, David Galas, Takashi Gojobori, Peter Hunter, Christian Jorgensen, Francine Kauffmann et al. Genome Medicine 2011, 3:43 (6 July 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A holistic and patient-centered strategy for tackling non-communicable diseases is proposed, based on the principles of predictive, preventive, personalized and participatory (P4) medicine.
	4.	Review Metabolomics of human breast cancer: new approaches for tumor typing and biomarker discovery Carsten Denkert, Elmar Bucher, Mika Hilvo, Reza Salek, Matej Orešič, Julian Griffin, Scarlet Brockmöller, Frederick Klauschen, Sibylle Loibl, Dinesh Barupal, Jan Budczies, Kristiina Iljin, Valentina Nekljudova, Oliver Fiehn Genome Medicine 2012, 4:37 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Denkert et al. review recent work showing that integrated metabolomic analyses can provide information on the stage, subtype and grade of breast tumors and give mechanistic insights into breast cancer.
	5.	Review Health care providers and direct-to-consumer access and advertising of genetic testing in the United States Melanie F Myers Genome Medicine 2011, 3:81 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Melanie Myers reviews the impact of advertising and selling of genetic testing direct to consumers on health care providers and asks whether providers are ready to deal with this issue.
	6.	Review Biomarkers in solid organ transplantation: establishing personalized transplantation medicine Silke Roedder, Matthew Vitalone, Purvesh Khatri, Minnie M Sarwal Genome Medicine 2011, 3:37 (8 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Minnie Sarwal and colleagues review the rocky road to regulatory approval in the search for biomarkers for organ transplants that will help predict the chances of success and increase graft survival.
	7.	Review Genome-wide association studies with metabolomics Jerzy Adamski Genome Medicine 2012, 4:34 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jerzy Adamski discusses the limitations of genome-wide association studies and presents examples of how metabolomics can overcome these limitations, focusing on metabolic diseases.
	8.	Open debate Open science versus commercialization: a modern research conflict? Timothy Caulfield, Shawn HE Harmon, Yann Joly Genome Medicine 2012, 4:17 (27 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary University researchers, particularly in genomics, are being asked to both commercialize their research and to disseminate it quickly through an open science model. Are these instructions in conflict?
	9.	Research Differential effects of dietary supplements on metabolomic profile of smokers versus non-smokers Robert C Spitale, Michelle Y Cheng, Kimberly A Chun, Emily S Gorell, Claudia A Munoz, Dale G Kern, Steve M Wood, Helen E Knaggs, Jacob Wulff, Kirk D Beebe, Anne Lynn S Chang Genome Medicine 2012, 4:14 (23 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A study of the effects of antioxidant dietary supplementation on the metabolomes and the skin of smokers and non-smokers suggests that antioxidants may be of more benefit to smokers.
	10.	Opinion From hepatitis to hepatocellular carcinoma: a proposed model for cross-talk between inflammation and epigenetic mechanisms Marion Martin, Zdenko Herceg Genome Medicine 2012, 4:8 (31 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Marion Martin and Zdenko Herceg discuss how cross-talk between inflammation and epigenetic mechanisms might be involved in the development of liver cancer.
	11.	Review Emerging patterns of genetic overlap across autoimmune disorders Corinne Richard-Miceli, Lindsey A Criswell Genome Medicine 2012, 4:6 (27 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Lindsey Criswell and Corinne Richard-Miceli review risk loci that are shared among autoimmune disorders and how this information might help to explain common disease mechanisms.
	12.	Editorial Metabolomics: the final frontier? Timothy D Veenstra Genome Medicine 2012, 4:40 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Timothy Veenstra introduces Genome Medicine's special issue on metabolomics of disease, and discusses the impact and opportunities presented by metabolomics, the final piece of the omics puzzle.
	13.	Review Tackling Ebola: new insights into prophylactic and therapeutic intervention strategies Emmie de Wit, Heinz Feldmann, Vincent J Munster Genome Medicine 2011, 3:5 (27 January 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary There is currently no effective treatment for human Ebolavirus infection, but research into vaccines and antiviral and antisense therapies in non-human primates is showing promise.
	14.	Research highlight Recycling side-effects into clinical markers for drug repositioning Miquel Duran-Frigola, Patrick Aloy Genome Medicine 2012, 4:3 (27 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Miquel Duran-Frigola and Patrick Aloy discuss a new computational approach to systematically exploring novel potential applications of already marketed drugs in distinct therapeutic areas.
	15.	Review Methods for the de-identification of electronic health records for genomic research Khaled El Emam Genome Medicine 2011, 3:25 (27 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary As electronic health records are increasingly used in research, Khaled El Emam reviews the need for effective de-identification methods to reduce the risk of re-identification for disclosed data.
	16.	Editorial Looking back at genomic medicine in 2011 Charles Auffray, Timothy Caulfield, Muin J Khoury, James R Lupski, Matthias Schwab, Timothy Veenstra Genome Medicine 2012, 4:9 (30 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An editorial by our Section Editors provides their highlights of the past year and hints at likely future developments in genomic medicine.
	17.	Review Future medical applications of single-cell sequencing in cancer Nicholas Navin, James Hicks Genome Medicine 2011, 3:31 (31 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Navin and Hicks provide an overview of recent methods for sequencing in single cells and discuss how this approach will be useful for detection of copy number variation for improving cancer outcomes.
	18.	Review Gut microbiome-host interactions in health and disease James M Kinross, Ara W Darzi, Jeremy K Nicholson Genome Medicine 2011, 3:14 (4 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The gut microbiome plays an important role in human disease and further understanding microbiome activity is crucial for the development of future personalized treatment strategies.
	19.	Research Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks Aaron M Newman, Natasha B Gallo, Lisa S Hancox, Norma J Miller, Carolyn M Radeke, Michelle A Maloney, James B Cooper, Gregory S Hageman, Don H Anderson, Lincoln V Johnson, Monte J Radeke Genome Medicine 2012, 4:16 (24 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Comparative transcriptome profiling of eye specimens, integrated with functionally enriched protein network analysis reveals candidate drug targets for treating age-related macular degeneration.
	20.	Research Metabolome in schizophrenia and other psychotic disorders: a general population-based study Matej Orešič, Jing Tang, Tuulikki Seppänen-Laakso, Ismo Mattila, Suoma E Saarni, Samuli I Saarni, Jouko Lönnqvist, Marko Sysi-Aho, Tuulia Hyötyläinen, Jonna Perälä, Jaana Suvisaari Genome Medicine 2011, 3:19 (23 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A population-based metabolomics study in Finland reveals disease-specific metabolic abnormalities associated with schizophrenia, compared with other psychotic disorders.
	21.	Editorial Genome Medicine: stem cells, genomics and translational research Stuart H Orkin Genome Medicine 2011, 3:34 (7 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An editorial by Guest Editor Stuart Orkin introduces this new series of articles, highlighting progress in genomic-scale studies of stem cells and cellular reprogramming that could impact medicine.
	22.	Musings Why have protein biomarkers not reached the clinic? Samir M Hanash Genome Medicine 2011, 3:66 (26 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Samir Hanash reflects on the reasons why there is a paucity of approved biomarkers for use in clinics, despite substantial advances in the understanding of the molecular basis of disease.
	23.	Review Integrating post-genomic approaches as a strategy to advance our understanding of health and disease Jing Tang, Chong Tan, Matej Oresic, Antonio Vidal-Puig Genome Medicine 2009, 1:35 (30 March 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary While the challenges of integrating very different types of data and perspectives of disease into a global model suitable for dissecting disease mechanisms and predicting therapeutic strategies are great, models based upon multiple datasets will become the basis that drives future research.
	24.	Review Mobile elements in the human genome: implications for disease Szilvia Solyom, Haig H Kazazian Genome Medicine 2012, 4:12 (24 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary With genome-scale technologies now allowing studies of mobile DNA elements in unprecedented detail, Solyom and Kazazian discuss the potential impact of recent findings for medicine.
	25.	Research highlight Combining DNA-microarray data in systemic lupus erythematosus Cornelis L Verweij, Saskia Vosslamber Genome Medicine 2011, 3:30 (31 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Verweij and Vosslamber discuss a new DNA-microrray meta-analysis approach that has identified genes and processes relevant to systemic lupus erythematosus, recently published in BMC Medicine.