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	1.	Review Inherited destiny? Genetics and gestational diabetes mellitus Richard M Watanabe Genome Medicine 2011, 3:18 (25 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Richard Watanabe reviews our understanding of the genetic basis of gestational diabetes mellitus and discusses whether this may be furthered by the recent dramatic gains in our knowledge of the genomics of other types of diabetes.
	2.	Research Pharmacogenetic testing affects choice of therapy among women considering tamoxifen treatment Wendy Lorizio, Hope Rugo, Mary S Beattie, Simone Tchu, Teri Melese, Michelle Melisko, Alan HB Wu, H Jeffrey Lawrence, Michele Nikoloff, Elad Ziv Genome Medicine 2011, 3:64 (4 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The choice of medication for breast cancer patients was changed after CYP2D6 genotyping, demonstrating for the first time that pharmacogenetics can shape clinical treatment decisions.
	3.	Research A whole genome association study of mother-to-child transmission of HIV in Malawi Bonnie R Joubert, Ethan M Lange, Nora Franceschini, Victor Mwapasa, Kari E North, Steven R Meshnick, the NIAID Center for HIV/AIDS Vaccine Immunology Genome Medicine 2010, 2:17 (1 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Mother-to-child HIV transmission in Malawian infants is associated with nine single nucleotide polymorphisms in six genes with roles in pregnancy, development, innate immunity and HIV-protein interaction.
	4.	Correspondence Planning for translational research in genomics Naomi Hawkins, Jantina de Vries, Paula Boddington, Jane Kaye, Catherine Heeney Genome Medicine 2009, 1:87 (29 September 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Careful planning during the early stages of a genomic research project will ensure the smooth translation of research findings into the clinic, even for projects whose immediate benefit is not apparent.
	5.	Research Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival Anita Sveen, Trude H Ågesen, Arild Nesbakken, Torleiv O Rognum, Ragnhild A Lothe, Rolf I Skotheim Genome Medicine 2011, 3:32 (27 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Exon microarray analyses of colorectal cancer tissues reveal different relative levels of transcriptome instability with associations with splicing factor expression and patient prognosis.
	6.	Research Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines Tewarit Sarachana, Rulun Zhou, Guang Chen, Husseini K Manji, Valerie W Hu Genome Medicine 2010, 2:23 (7 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary 43 microRNAs with target genes associated with autism are dysregulated in samples from patients with this condition, suggesting that microRNAs contribute to the gene expression alterations and consequently the physiological abnormalities underlying autistic spectrum disorders.
	7.	Research Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme Kristian Ovaska, Marko Laakso, Saija Haapa-Paananen, Riku Louhimo, Ping Chen, Viljami Aittomäki, Erkka Valo, Javier Núñez-Fontarnau, Ville Rantanen, Sirkku Karinen, Kari Nousiainen, Anna-Maria Lahesmaa-Korpinen, Minna Miettinen, Lilli Saarinen, Pekka Kohonen, Jianmin Wu, Jukka Westermarck, Sampsa Hautaniemi Genome Medicine 2010, 2:65 (7 September 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Anduril, a computational framework that allows for rapid integration of heterogeneous molecular and clinical information, identifies Moesin as a novel gene associated with survival in glioblastoma multiforme and represents a valuable tool for systems analyses.
	8.	Review Metabolomics of human breast cancer: new approaches for tumor typing and biomarker discovery Carsten Denkert, Elmar Bucher, Mika Hilvo, Reza Salek, Matej Orešič, Julian Griffin, Scarlet Brockmöller, Frederick Klauschen, Sibylle Loibl, Dinesh Barupal, Jan Budczies, Kristiina Iljin, Valentina Nekljudova, Oliver Fiehn Genome Medicine 2012, 4:37 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Denkert et al. review recent work showing that integrated metabolomic analyses can provide information on the stage, subtype and grade of breast tumors and give mechanistic insights into breast cancer.
	9.	Correspondence Systems medicine and integrated care to combat chronic noncommunicable diseases Jean Bousquet, Josep M Anto, Peter J Sterk, Ian M Adcock, Kian Chung, Josep Roca, Alvar Agusti, Chris Brightling, Anne Cambon-Thomsen, Alfredo Cesario, Sonia Abdelhak, Stylianos E Antonarakis, Antoine Avignon, Andrea Ballabio, Eugenio Baraldi, Alexander Baranov, Thomas Bieber, Joël Bockaert, Samir Brahmachari, Christian Brambilla, Jacques Bringer, Michel Dauzat, Ingemar Ernberg, Leonardo Fabbri, Philippe Froguel, David Galas, Takashi Gojobori, Peter Hunter, Christian Jorgensen, Francine Kauffmann et al. Genome Medicine 2011, 3:43 (6 July 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A holistic and patient-centered strategy for tackling non-communicable diseases is proposed, based on the principles of predictive, preventive, personalized and participatory (P4) medicine.
	10.	Research Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes Iain J Gallagher, Camilla Scheele, Pernille Keller, Anders R Nielsen, Judit Remenyi, Christian P Fischer, Karim Roder, John Babraj, Claes Wahlestedt, Gyorgy Hutvagner, Bente K Pedersen, James A Timmons Genome Medicine 2010, 2:9 (1 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Muscle mRNA expression is invariant with respect to diabetes status, but coordinated changes in numerous microRNAs may control protein abundance and affect skeletal muscle insulin resistance, a critical component of the disease.
	11.	Research Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling Ross L Prentice, Sophie Paczesny, Aaron Aragaki, Lynn M Amon, Lin Chen, Sharon J Pitteri, Martin McIntosh, Pei Wang, Tina Buson Busald, Judith Hsia, Rebecca D Jackson, Jacques E Rossouw, JoAnn E Manson, Karen Johnson, Charles Eaton, Samir M Hanash Genome Medicine 2010, 2:48 (28 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In-depth proteome analysis of samples from postmenopausal women identifies the level of beta-2 microglobulin and insulin-like growth factor binding protein as biomarkers for risk of coronary heart disease and stroke respectively.
	12.	Review Gut microbiome-host interactions in health and disease James M Kinross, Ara W Darzi, Jeremy K Nicholson Genome Medicine 2011, 3:14 (4 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The gut microbiome plays an important role in human disease and further understanding microbiome activity is crucial for the development of future personalized treatment strategies.
	13.	Commentary Predicting prognosis of breast cancer with gene signatures: are we lost in a sea of data? Takayuki Iwamoto, Lajos Pusztai Genome Medicine 2010, 2:81 (12 November 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Why do the many gene signatures which claim to predict breast cancer prognosis vary so much in the genes they contain?
	14.	Database Collaboratively charting the gene-to-phenotype network of human congenital heart defects Roland Barriot, Jeroen Breckpot, Bernard Thienpont, Sylvain Brohée, Steven Van Vooren, Bert Coessens, Leon-Charles Tranchevent, Peter Van Loo, Marc Gewillig, Koenraad Devriendt, Yves Moreau Genome Medicine 2010, 2:16 (1 March 2010) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology \| Editor’s summary The development of a specialized portal for collaborative annotation and analysis of gene-phenotype networks in congenital heart defects using a Wiki platform highlights this technology’s potential for systems biology studies of other complex biological processes.
	15.	Research High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-κB-complex-dependent gene expression in human heart failure Mun-Kit Choy, Mehregan Movassagh, Lee Siggens, Ana Vujic, Martin Goddard, Ana Sánchez, Neil Perkins, Nichola Figg, Martin Bennett, Jason Carroll, Roger Foo Genome Medicine 2010, 2:37 (14 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A cooperative transcription factor complex involving p53, NF-kappa-B and STAT3 is responsible for the transcriptional regulation of miRNA-21, a microRNA relevant for the pathology of heart failure.
	16.	Correspondence Strengthening the reporting of genetic risk prediction studies: the GRIPS statement A Cecile JW Janssens, John PA Ioannidis, Cornelia M van Duijn, Julian Little, Muin J Khoury, the GRIPS Group Genome Medicine 2011, 3:16 (15 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary With the recent increase in genetic risk prediction studies, a statement has been compiled to provide guidelines for the complete and accurate reporting of research methodology and findings.
	17.	Review Integrating post-genomic approaches as a strategy to advance our understanding of health and disease Jing Tang, Chong Tan, Matej Oresic, Antonio Vidal-Puig Genome Medicine 2009, 1:35 (30 March 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary While the challenges of integrating very different types of data and perspectives of disease into a global model suitable for dissecting disease mechanisms and predicting therapeutic strategies are great, models based upon multiple datasets will become the basis that drives future research.
	18.	Research highlight Recycling side-effects into clinical markers for drug repositioning Miquel Duran-Frigola, Patrick Aloy Genome Medicine 2012, 4:3 (27 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Miquel Duran-Frigola and Patrick Aloy discuss a new computational approach to systematically exploring novel potential applications of already marketed drugs in distinct therapeutic areas.
	19.	Review Tackling Ebola: new insights into prophylactic and therapeutic intervention strategies Emmie de Wit, Heinz Feldmann, Vincent J Munster Genome Medicine 2011, 3:5 (27 January 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary There is currently no effective treatment for human Ebolavirus infection, but research into vaccines and antiviral and antisense therapies in non-human primates is showing promise.
	20.	Editorial Metabolomics: the final frontier? Timothy D Veenstra Genome Medicine 2012, 4:40 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Timothy Veenstra introduces Genome Medicine's special issue on metabolomics of disease, and discusses the impact and opportunities presented by metabolomics, the final piece of the omics puzzle.
	21.	Commentary Human genomics and preparedness for infectious threats Nicole F Dowling, Marta Gwinn, Alison Mawle Genome Medicine 2009, 1:119 (29 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Research activity during infectious disease outbreaks maximizes limited resources, enhances gains in scientific knowledge, and ultimately increases levels of preparedness.
	22.	Review Genetic overlap between autism, schizophrenia and bipolar disorder Liam S Carroll, Michael J Owen Genome Medicine 2009, 1:102 (30 October 2009) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Overlap between the loci that predispose to autism, schizophrenia and bipolar disorder suggests shared pathogenic mechanisms and challenges the view that these disorders are unrelated diagnostic entities.
	23.	Review Methods for the de-identification of electronic health records for genomic research Khaled El Emam Genome Medicine 2011, 3:25 (27 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary As electronic health records are increasingly used in research, Khaled El Emam reviews the need for effective de-identification methods to reduce the risk of re-identification for disclosed data.
	24.	Review Biomarkers in solid organ transplantation: establishing personalized transplantation medicine Silke Roedder, Matthew Vitalone, Purvesh Khatri, Minnie M Sarwal Genome Medicine 2011, 3:37 (8 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Minnie Sarwal and colleagues review the rocky road to regulatory approval in the search for biomarkers for organ transplants that will help predict the chances of success and increase graft survival.
	25.	Review Future medical applications of single-cell sequencing in cancer Nicholas Navin, James Hicks Genome Medicine 2011, 3:31 (31 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Navin and Hicks provide an overview of recent methods for sequencing in single cells and discuss how this approach will be useful for detection of copy number variation for improving cancer outcomes.