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The genomics of preterm birth: from animal models to human studies
Katherine Y Bezold, Minna K Karjalainen, Mikko Hallman, Kari Teramo, Louis J Muglia Genome Medicine 2013, 5:34 (29 April 2013)
Abstract | Full text | PDF
| PubMed
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Editor’s summary
Louis Muglia and colleagues review the genetics and genomics of pre-term birth and birth timing, discussing the limitations of animal models and the progress of human studies.
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Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model
Corey S Martin, Akemi Moriyama, Leonard I Zon Genome Medicine 2011, 3:83 (29 December 2011)
Abstract | Full text | PDF
| PubMed
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Editor’s summary
Martin, Moriyama and Zon review the advantages of zebrafish for studying early development of blood cells and highlight recent discoveries using this model that show clinical promise.
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Are randomized trials obsolete or more important than ever in the genomic era?
John PA Ioannidis, Muin J Khoury Genome Medicine 2013, 5:32 (18 April 2013)
Abstract | Full text | PDF
| PubMed
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Editor’s summary
John Ioannidis and Muin Khoury reflect on how advances in the field of genomics are questioning the need for randomized clinical trials and revolutionizing their design. |
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An imprinted rheumatoid arthritis methylome signature
reflects pathogenic phenotype
John W Whitaker, Robert Shoemaker, David L Boyle, Josh Hillman, David Anderson, Wei Wang, Gary S Firestein Genome Medicine 2013, 5:40 (30 April 2013)
Abstract | Provisional PDF
| PubMed
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Editor’s summary
Key genes in cultured rheumatoid arthritis cells are stably differentially methylated compared to osteoarthritis or normal cells, and are potential therapeutic targets. |
