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Metabolomics of human breast cancer: new approaches for tumor typing and biomarker discovery
Carsten Denkert, Elmar Bucher, Mika Hilvo, Reza Salek, Matej Orešič, Julian Griffin, Scarlet Brockmöller, Frederick Klauschen, Sibylle Loibl, Dinesh Barupal, Jan Budczies, Kristiina Iljin, Valentina Nekljudova, Oliver Fiehn Genome Medicine 2012, 4:37 (30 April 2012)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Denkert et al. review recent work showing that integrated metabolomic analyses can provide information on the stage, subtype and grade of breast tumors and give mechanistic insights into breast cancer.
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Genome-wide association studies with metabolomics
Jerzy Adamski Genome Medicine 2012, 4:34 (30 April 2012)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Jerzy Adamski discusses the limitations of genome-wide association studies and presents examples of how metabolomics can overcome these limitations, focusing on metabolic diseases.
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Metabolomics: the final frontier?
Timothy D Veenstra Genome Medicine 2012, 4:40 (30 April 2012)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Timothy Veenstra introduces Genome Medicine's special issue on metabolomics of disease, and discusses the impact and opportunities presented by metabolomics, the final piece of the omics puzzle.
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Genetic overlap between autism, schizophrenia and bipolar disorder
Liam S Carroll, Michael J Owen Genome Medicine 2009, 1:102 (30 October 2009)
Abstract | Full text | PDF | PubMed |
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Editor’s summary
Overlap between the loci that predispose to autism, schizophrenia and bipolar disorder suggests shared pathogenic mechanisms and challenges the view that these disorders are unrelated diagnostic entities.
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Differential effects of dietary supplements on metabolomic profile of smokers versus non-smokers
Robert C Spitale, Michelle Y Cheng, Kimberly A Chun, Emily S Gorell, Claudia A Munoz, Dale G Kern, Steve M Wood, Helen E Knaggs, Jacob Wulff, Kirk D Beebe, Anne Lynn S Chang Genome Medicine 2012, 4:14 (23 February 2012)
Abstract | Full text | PDF | PubMed
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Editor’s summary
A study of the effects of antioxidant dietary supplementation
on the metabolomes and the skin of smokers and non-smokers suggests that antioxidants may be of more benefit to smokers.
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Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancer
Zsuzsanna Ament, Mojgan Masoodi, Julian L Griffin Genome Medicine 2012, 4:32 (30 April 2012)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Julian Griffin and colleagues review the role metabolomics has played in elucidating the roles of peroxisome proliferator-activated receptors in systemic metabolism regulation.
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Quantitative high-throughput metabolomics: a new era in epidemiology and genetics
Mika Ala-Korpela, Antti J Kangas, Pasi Soininen Genome Medicine 2012, 4:36 (30 April 2012)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Mika Ala-Korpela and colleagues advocate the use of multiple metabolomic markers to get a detailed, quantitative picture of disease etiology, particularly for complex diseases.
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The futility of genomic counseling: essential role of electronic health records
John Belmont, Amy L McGuire Genome Med 2009, 1:48 (8 May 2009)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Integration of a dynamic uniform electronic health record is essential for the success of patient counseling on the basis of genome-wide data.
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