Genome Medicine | Volume 5 Issue 4

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	Volume 5 Issue 4
	Comment
	Editorial Microbial genomics: an increasingly revealing interface in human health and disease Martin L Hibberd Genome Medicine 2013, 5:31 (18 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Guest Editor Martin Hibberd highlights advances in genomics, metagenomics and other high-throughput approaches for studying human-microbe interactions in health and disease, and the applications for medicine.
	Musings Are randomized trials obsolete or more important than ever in the genomic era? John PA Ioannidis, Muin J Khoury Genome Medicine 2013, 5:32 (18 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary John Ioannidis and Muin Khoury reflect on how advances in the field of genomics are questioning the need for randomized clinical trials and revolutionizing their design.
	Musings The Human Genome Organisation: towards next-generation ethics Bartha Knoppers, Adrian Thorogood, Ruth Chadwick Genome Medicine 2013, 5:38 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Knoppers, Thorogood and Chadwick muse over the evolution of ethical statements and policy over the course of the human genome project and beyond, marking 10 years since its completion.
	Research highlight Plasma-seq: a novel strategy for metastatic prostate cancer analysis Caitlin Farris, Jeffrey M Trimarchi Genome Medicine 2013, 5:35 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Caitlin Farris and Jeffrey Trimarchi discuss how a new non-invasive approach for personalized diagnosis of prostate cancer shows promise for the clinic, being both time- and cost-effective.
	Review
	Review Genomics and outbreak investigation: from sequence to consequence Esther R Robinson, Timothy M Walker, Mark J Pallen Genome Medicine 2013, 5:36 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mark Pallen and co-authors review advances in applying high-throughput sequencing approaches for outbreak investigation (focusing on bacterial infections), and discuss the implications for clinical microbiology.
	Review The genomics of preterm birth: from animal models to human studies Katherine Y Bezold, Minna K Karjalainen, Mikko Hallman, Kari Teramo, Louis J Muglia Genome Medicine 2013, 5:34 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Louis Muglia and colleagues review the genetics and genomics of pre-term birth and birth timing, discussing the limitations of animal models and the progress of human studies.
	Review Protein-protein interaction networks: probing disease mechanisms using model systems Uros Kuzmanov, Andrew Emili Genome Medicine 2013, 5:37 (30 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Kuzmanov and Emili review recent advances in protein-protein interaction studies from various model organisms, shedding light on the mechanisms and possible treatments for human disease.
	Research
	Research Tumor associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing Ellen Heitzer, Peter Ulz, Jelena Belic, Stefan Gutschi, Franz Quehenberger, Katja Fischereder, Theresa Benezeder, Martina Auer, Carina Pischler, Sebastian Mannweiler, Martin Pichler, Florian Eisner, Martin Haeusler, Sabine Riethdorf, Klaus Pantel, Hellmut Samonigg, Gerald Hoefler, Herbert Augustin, Jochen B Geigl, Michael R Speicher Genome Medicine 2013, 5:30 (5 April 2013) Abstract \| Provisional PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Genomic monitoring of prostate cancer using non-invasive plasma DNA sequencing can be carried out quickly and cheaply using a benchtop high-throughput sequencer.
	Research Isoform level expression profiles provide better cancer signatures than gene level expression profiles ZhongFa Zhang, Sharmistha Pal, Yingtao Bi, Julia Tchou, Ramana V Davuluri Genome Medicine 2013, 5:33 (17 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Expression profiles at the isoform level perform better than those at the gene level to discriminate between cancer cell lines and non-oncogenic cells, regardless of tissue of origin.
	Research An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype John W Whitaker, Robert Shoemaker, David L Boyle, Josh Hillman, David Anderson, Wei Wang, Gary S Firestein Genome Medicine 2013, 5:40 (30 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Key genes in cultured rheumatoid arthritis cells are stably differentially methylated compared to osteoarthritis or normal cells, and are potential therapeutic targets.
	Method Development and validation of a robust automated analysis of plasma phospholipid fatty acids for metabolic phenotyping of large epidemiological studies Laura Y Wang, Keith Summerhill, Carmen Rodriguez-Canas, Ian Mather, Pinal Patel, Michael Eiden, Stephen Young, Nita G Forouhi, Albert Koulman Genome Medicine 2013, 5:39 (25 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A fully automated high-throughput method provides proof-of-concept that fatty acid profiling of human plasma is achievable for metabolic phenotyping in large epidemiological and genetic studies.