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Highly Accessed Review

Novel approaches for the identification of biomarkers of aggressive prostate cancer

Yunee Kim1 and Thomas Kislinger12*

Author Affiliations

1 Department of Medical Biophysics, University of Toronto, Toronto, Canada M5G 1L7

2 Princess Margaret Cancer Center, University Health Network, Toronto, Canada M5G 1L7

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Genome Medicine 2013, 5:56  doi:10.1186/gm460

Published: 28 June 2013

Abstract

The ability to distinguish indolent from aggressive prostate tumors remains one of the greatest challenges in the management of this disease. Ongoing efforts to establish a panel of molecular signatures, comprising gene expression profiles, proteins, epigenetic patterns, or a combination of these alterations, are being propelled by rapid advancements in 'omics' technologies. The identification of such biomarkers in biological fluids is an especially attractive goal for clinical applications. Here, we summarize recent progress in the identification of candidate prognostic biomarkers of prostate cancer using biological fluid samples.