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Highly Accessed Review

Genetic determinants of metabolism in health and disease: from biochemical genetics to genome-wide associations

Steven L Robinette, Elaine Holmes, Jeremy K Nicholson* and Marc E Dumas*

Genome Medicine 2012, 4:30  doi:10.1186/gm329

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Appreciation of special susceptibility through metabolomics

Heikki Savolainen   (2012-07-10 16:39)  Ministry of Social Affairs and Health, Tampere, Finland

Dear Editor,

The review correctly points out that the use of metabolomics is already in the clinical routine (1).

By applying the idea of individual susceptibility, it was found that carriers of slow N-acetyltransferase activity may excrete more slowly the amine metabolites of organic diisocyanates (2). If this trait was associated with a heterozygous antitrypsin phenotype, the risk of developing an occupational asthma in work involving diisocyanates was threefold (Confidence interval 1.2-8). Thus it seems that the combination of traits is even more important than specifying single changes.

1. Robinette SL, Holmes E, Nicholson JK, Dumas ME. Genetic determinants of metabolism in health and disease: from biochemical genetics to genome-wide associations. Genome Medicine 2012, 4:30

2. Berode M, Jost M, Ruegger M, Savolainen H. Host factors in occupational diisocyanate asthma: a Swiss longitudinal study. Int Arch Occup Environ Hlth 2005, 78:158

Competing interests

None

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