Email updates

Keep up to date with the latest news and content from Genome Medicine and BioMed Central.

Journal App

google play app store
Research highlight

Flirting with CFTR modifier genes at happy hour

Marc Blondel

Author Affiliations

Institut National de la Santé et de la Recherche Médicale UMR1078; Université de Bretagne Occidentale, Faculté de Médecine et des Sciences de la Santé; Etablissement Français du Sang (EFS) Bretagne; CHRU Brest, Hôpital Morvan, Laboratoire de Génétique Moléculaire, Brest, F-29200, France

Genome Medicine 2012, 4:98  doi:10.1186/gm399


See related Research: http://genomemedicine.com/content/4/12/103

Published: 27 December 2012

Abstract

An original yeast-based phenomic model for DeltaF508 CFTR, by far the most prevalent allele of the CFTR gene responsible for cystic fibrosis, has been developed by the groups of Elizabeth A Miller and John L Hartman. This model allows potential modifier genes of the DeltaF508 CFTR allele to be uncovered. Hence, brewer's yeast Saccharomyces cerevisiae is not only needed at happy hour, it also represents an invaluable tool for human geneticists.