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Broad applications of single-cell nucleic acid analysis in biomedical research

Michael Wigler

Author Affiliations

Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, NY, 11724, USA

Genome Medicine 2012, 4:79  doi:10.1186/gm380

Published: 30 October 2012

First paragraph (this article has no abstract)

Recent publications have demonstrated the feasibility and utility of sequencing DNA or RNA from single cells [1,2]. The power of these tools lies in their ability to reveal in mixtures of cells the identity and state of subpopulations. The advantage of single-cell analysis over merely deep sequencing, whether for DNA or RNA, lies in the ability of the former to isolate differences and to phase possibly multiple differences within subpopulations. The future applications of these technologies are the topic of this brief article.