Genome Medicine | Volume 4 Issue 1

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	Volume 4 Issue 1
	Comment
	Editorial Looking back at genomic medicine in 2011 Charles Auffray, Timothy Caulfield, Muin J Khoury, James R Lupski, Matthias Schwab, Timothy Veenstra Genome Medicine 2012, 4:9 (30 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An editorial by our Section Editors provides their highlights of the past year and hints at likely future developments in genomic medicine.
	Research highlight Recycling side-effects into clinical markers for drug repositioning Miquel Duran-Frigola, Patrick Aloy Genome Medicine 2012, 4:3 (27 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Miquel Duran-Frigola and Patrick Aloy discuss a new computational approach to systematically exploring novel potential applications of already marketed drugs in distinct therapeutic areas.
	Research highlight Improving bioinformatic pipelines for exome variant calling Hanlee P Ji Genome Medicine 2012, 4:7 (30 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hanlee Ji discusses the Atlas2 suite, a new set of tools for calling variants in exome sequencing data that is faster and easier to use than comparable tools and could thus be useful in diagnostics.
	Research highlight Drug transporter regulation in tumors by DNA methylation Oliver Zolk, Martin F Fromm Genome Medicine 2012, 4:10 (31 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Oliver Zolk and Martin Fromm highlight a recent observation that uptake transporters for anticancer drugs are epigenetically regulated in hepatocellular carcinoma.
	Review
	Review Emerging patterns of genetic overlap across autoimmune disorders Corinne Richard-Miceli, Lindsey A Criswell Genome Medicine 2012, 4:6 (27 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Lindsey Criswell and Corinne Richard-Miceli review risk loci that are shared among autoimmune disorders and how this information might help to explain common disease mechanisms.
	Opinion From hepatitis to hepatocellular carcinoma: a proposed model for cross-talk between inflammation and epigenetic mechanisms Marion Martin, Zdenko Herceg Genome Medicine 2012, 4:8 (31 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Marion Martin and Zdenko Herceg discuss how cross-talk between inflammation and epigenetic mechanisms might be involved in the development of liver cancer.
	Report
	Meeting report The long journey of stem cell therapeutics Sarah Crawford Genome Medicine 2012, 4:5 (27 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sarah Crawford presents the highlights and roadblocks of therapeutic applications from the Euroepistem 2011 meeting on 'Epigenomic Programming and Stem Cells for Drug Discovery'.
	Meeting report A year of great leaps in genome research Jingde Zhu Genome Medicine 2012, 4:4 (30 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jingde Zhu presents the recent progress made and highlights of the Beijing Genomics Institute's 6th International Conference on Genomics (ICG-VI), held in Shenzhen, China.
	Research
	Research Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia Matej Orešič, Tuulikki Seppänen-Laakso, Daqiang Sun, Jing Tang, Sebastian Therman, Rachael Viehman, Ulla Mustonen, Theo G van Erp, Tuulia Hyötyläinen, Paul Thompson, Arthur W Toga, Matti O Huttunen, Jaana Suvisaari, Jaakko Kaprio, Jouko Lönnqvist, Tyrone D Cannon Genome Medicine 2012, 4:1 (18 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Lipidomic, imaging and neurocognitive analysis of twin pairs reveals lipid biomarkers linked to decreased cognitive speed and potentially increased susceptibility to infection in schizophrenia.
	Research The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls Marcus Ronninger, Yongjing Guo, Klementy Shchetynsky, Andrew Hill, Mohsen Khademi, Tomas Olsson, Padmalatha S Reddy, Maria Seddighzadeh, James D Clark, Lih-Ling Lin, Margot O'Toole, Leonid Padyukov Genome Medicine 2012, 4:2 (20 January 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Genotyping and phenotyping of cells from rheumatoid arthritis patients and healthy controls reveals different patterns of expression for the protein tyrosine phosphatase non-receptor 22 gene.