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PPAR action in insulin resistance unraveled by metabolomics: potential clinical implications

Andrew D Patterson and Jeffrey M Peters*

Author Affiliations

Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA

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Genome Medicine 2011, 3:54  doi:10.1186/gm270

Published: 23 August 2011

Abstract

Metabolomic analysis will provide the next large set of clues to further our understanding of human health and disease. A recent study has elucidated the significant differences in the metabolomes of adipocytes, serum and an adipocyte cell line after activation of two nuclear receptors, peroxisome proliferator activated receptor β/δ (PPARβ/δ) and PPARγ. These findings hold great promise for explaining fundamental differences in the mechanisms of PPAR agonists and for identifying targets for the treatment of diabetes.

See related research article: http://genomebiology.com/2011/12/8/R75 webcite