Genome Medicine | Volume 3 Issue 8

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	Volume 3 Issue 8
	Comment
	Musings Are diagnostic and public health bacteriology ready to become branches of genomic medicine? Mark J Pallen, Nicholas J Loman Genome Medicine 2011, 3:53 (23 August 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary As next-generation sequencing technologies continue to evolve, Mark Pallen and Nicholas Loman muse on the impact of whole genome sequencing on diagnostic and public health microbiology.
	Research highlight PPAR action in insulin resistance unraveled by metabolomics: potential clinical implications Andrew D Patterson, Jeffrey M Peters Genome Medicine 2011, 3:54 (23 August 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Patterson and Peters highlight a new study by Griffin and colleagues showing different effects of two peroxisome proliferator activated receptors on fatty acid metabolism.
	Research highlight MicroRNAs miR-221 and miR-222: a new level of regulation in aggressive breast cancer Maitri Y Shah, George A Calin Genome Medicine 2011, 3:56 (31 August 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Shah and Calin highlight a study by Stinson et al. showing that expression of two microRNAs promote an aggressive form of metastatic breast cancer by triggering epithelial-to-mesenchymal transition.
	Review
	Review Genetics and genomics of radiotherapy toxicity: towards prediction Catharine M West, Gillian C Barnett Genome Medicine 2011, 3:52 (23 August 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Catharine West and Gillian Barnett review the latest advances in radiotherapy and the recent genome-wide studies that have identified genetic variants linked to radiotoxicity.
	Review Gene expression and hypoxia in breast cancer Elena Favaro, Simon Lord, Adrian L Harris, Francesca M Buffa Genome Medicine 2011, 3:55 (26 August 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Francesca Buffa, Adrian Harris and colleagues review gene and microRNA expression signatures for tumor-associated hypoxia and their potential for diagnosis and treatment of breast cancer.
	Research
	Research Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort Katherine R Smith, Vijayaprakash Suppiah, Kate O'Connor, Thomas Berg, Martin Weltman, Maria Abate, Ulrich Spengler, Margaret Bassendine, Gail Matthews, William L Irving, Elizabeth Powell, Stephen Riordan, Golo Ahlenstiel, Graeme J Stewart, Melanie Bahlo, Jacob George, David R Booth, the International Hepatitis C Genetics Consortium (IHCGC) Genome Medicine 2011, 3:57 (31 August 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Novel variants in the IL28B gene region, which predict lack of response to conventional treatment of hepatitis C virus, are identified through massively parallel sequencing using pooled DNA.