Research
Predictive genetic testing for the identification of high-risk groups: a simulation study on the impact of predictive ability
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* Corresponding author: A CJW Janssens a.janssens@erasmusmc.nl
1 Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
2 Office of Minority Health and Health Disparities, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30341, USA
3 Office of Public Health Genomics, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30341, USA
Genome Medicine 2011, 3:51 doi:10.1186/gm267
Published: 28 July 2011Additional files
Additional file 1:
Supplementary tables and supplementary figure legends. A table listing genotype ORs and genotypic frequencies of the markers included in the AMD simulation and figure legends for Additional files 2 to 4.
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Additional file 2:
Supplementary Figure S1. A figure showing the change in specificity and NPV for different thresholds.
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Additional file 3:
Supplementary Figure S2. A figure showing the sensitivity, specificity, PPV and NPV for different frequencies of the population at high risk.
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Additional file 4:
Supplementary Figure S3. A file showing the distribution of predicted risks in individuals with and without AMD.
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