Genome Medicine | Volume 3 Issue 6

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	Volume 3 Issue 6
	Comment
	Editorial Genome Medicine: stem cells, genomics and translational research Stuart H Orkin Genome Medicine 2011, 3:34 (7 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An editorial by Guest Editor Stuart Orkin introduces this new series of articles, highlighting progress in genomic-scale studies of stem cells and cellular reprogramming that could impact medicine.
	Musings Genomic and stem cell policy issues: more alike than different? Mary A Majumder Genome Medicine 2011, 3:35 (7 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mary Majumder muses on the convergence of stem cell and genomics policy discussions, highlighting common areas of concern such as communication, consent, commercialization and clinical integration.
	Research highlight microRNAs become macro players in somatic cell reprogramming Tamer T Onder, George Q Daley Genome Medicine 2011, 3:40 (22 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Onder and Daley highlight a new study by Morrisey and colleagues showing that embryonic stem cells can be reprogrammed entirely with microRNAs, without the use of transcription factors.
	Research highlight Are enrollment sites the key to optimizing participation in genetic studies? Gert Helgesson Genome Medicine 2011, 3:41 (28 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gert Helgesson discusses a recent study by Lanfear and colleagues that identifies enrolment site as the most important factor associated with patient recruitment in a genetic study.
	Review
	Review Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease Alvaro Rada-Iglesias, Joanna Wysocka Genome Medicine 2011, 3:36 (7 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Wysocka and Rada-Iglesias review advances in epigenomic profiling of human pluripotent stem cells, highlighting the roles of regulatory elements and the implications for disease.
	Review Biomarkers in solid organ transplantation: establishing personalized transplantation medicine Silke Roedder, Matthew Vitalone, Purvesh Khatri, Minnie M Sarwal Genome Medicine 2011, 3:37 (8 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Minnie Sarwal and colleagues review the rocky road to regulatory approval in the search for biomarkers for organ transplants that will help predict the chances of success and increase graft survival.
	Report
	Meeting report Exploring the ELSI universe: critical issues in the evolution of human genomic research Jill M Oliver, Amy L McGuire Genome Medicine 2011, 3:38 (21 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Oliver and McGuire report the highlights of the NHGRI’s Ethical, Legal, and Social Implications Research Program 2011 Congress, ‘Exploring the ELSI Universe’.
	Research
	Research Factors influencing patient willingness to participate in genetic research after a myocardial infarction David E Lanfear, Philip G Jones, Sharon Cresci, Fengming Tang, Saif S Rathore, John A Spertus Genome Medicine 2011, 3:39 (15 June 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Patient enrolment rates in genetic research might be more strongly influenced by factors relating to the site of recruitment than patient-level factors, revealed by a survey-based study from TRIUMPH.
	Research Genetic variants in the MRPS30 region and postmenopausal breast cancer risk Ying Huang, Dennis G Ballinger, James Y Dai, Ulrike Peters, David A Hinds, David R Cox, Erica Beilharz, Rowan T Chlebowski, Jacques E Rossouw, Anne McTiernan, Thomas Rohan, Ross L Prentice Genome Medicine 2011, 3:42 (24 June 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Inclusion of hormonal and dietary exposure information links the MRPS30 genomic region to postmenopausal breast cancer risk, showing the importance of genotype by environment interactions.