Genome Medicine | Volume 3 Issue 5

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	Volume 3 Issue 5
	Comment
	Research highlight Personalizing carbamazepine therapy Taisei Mushiroda, Yusuke Nakamura Genome Medicine 2011, 3:28 (30 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mushiroda and Nakamura highlight recent studies that could facilitate the development of genetic tests to predict individuals at risk for serious adverse reactions to carbamazepine.
	Research highlight Combining DNA-microarray data in systemic lupus erythematosus Cornelis L Verweij, Saskia Vosslamber Genome Medicine 2011, 3:30 (31 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Verweij and Vosslamber discuss a new DNA-microrray meta-analysis approach that has identified genes and processes relevant to systemic lupus erythematosus, recently published in BMC Medicine.
	Review
	Review Future medical applications of single-cell sequencing in cancer Nicholas Navin, James Hicks Genome Medicine 2011, 3:31 (31 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Navin and Hicks provide an overview of recent methods for sequencing in single cells and discuss how this approach will be useful for detection of copy number variation for improving cancer outcomes.
	Report
	Meeting report Diverse perspectives on the current state of genomic medicine: has the revolution begun? Dhara M MacDermed, Liliana Uribe-Bruce Genome Medicine 2011, 3:27 (25 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Future of Genomic Medicine IV meeting held in La Jolla, California, USA, 3-4 March 2011.
	Meeting report Massively parallel rare disease genetics Kathleen H Burns, Aravinda Chakravarti Genome Medicine 2011, 3:29 (30 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the ‘Genomic Disorders 2011 - The Genomics of Rare Diseases’ meeting, Wellcome Trust Sanger Institute, Hinxton, UK, 23-26 March 2011.
	Research
	Research Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival Anita Sveen, Trude H Ågesen, Arild Nesbakken, Torleiv O Rognum, Ragnhild A Lothe, Rolf I Skotheim Genome Medicine 2011, 3:32 (27 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Exon microarray analyses of colorectal cancer tissues reveal different relative levels of transcriptome instability with associations with splicing factor expression and patient prognosis.
	Research The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease Carmen Antúnez, Mercè Boada, Antonio González-Pérez, Javier Gayán, Reposo Ramírez-Lorca, Juan Marín, Isabel Hernández, Concha Moreno-Rey, Francisco Morón, Jesús López-Arrieta, Ana Mauleón, Maitée Rosende-Roca, Fuensanta Noguera-Perea, Agustina Legaz-García, Laura Vivancos-Moreau, Juan Velasco, José Carrasco, Montserrat Alegret, Martirio Antequera-Torres, Salvadora Manzanares, Alejandro Romo, Irene Blanca, Susana Ruiz, Anna Espinosa, Sandra Castaño, Blanca García, Begoña Martínez-Herrada, Georgina Vinyes, Asunción Lafuente, James T Becker et al. Genome Medicine 2011, 3:33 (31 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A genome-wide association study in a Spanish population identifies a novel variant associated with Alzheimer’s disease, within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster.