Genome Medicine | Volume 3 Issue 4

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	Volume 3 Issue 4
	Comment
	Research highlight From sequence to functional understanding: the difficult road ahead Periklis Makrythanasis, Stylianos E Antonarakis Genome Medicine 2011, 3:21 (6 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A recent functional screen of non-synonymous variants of a new gene highlights the value and necessity of characterizing the functional consequences of each genomic variant.
	Research highlight Genome interrupted: sequencing of prostate cancer reveals the importance of chromosomal rearrangements Akash Kumar, Jay Shendure, Peter S Nelson Genome Medicine 2011, 3:23 (19 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Chromosomal rearrangements might be more important than point mutations as a driving force in prostate cancer, recently revealed by whole genome sequencing of primary tumors.
	Research highlight Testing for rare variant associations in complex diseases Jennifer Asimit, Eleftheria Zeggini Genome Medicine 2011, 3:24 (27 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Asimit and Zeggini highlight a new methodology developed by Ionita Laza et al. for detecting rare variants associated with a risk or protective effect in complex disease.
	Review
	Review Methods for the de-identification of electronic health records for genomic research Khaled El Emam Genome Medicine 2011, 3:25 (27 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary As electronic health records are increasingly used in research, Khaled El Emam reviews the need for effective de-identification methods to reduce the risk of re-identification for disclosed data.
	Review Predicting treatment outcome in classical Hodgkin lymphoma: genomic advances Enrico Derenzini, Anas Younes Genome Medicine 2011, 3:26 (28 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Derenzini and Younes review advances in genomic technologies that have allowed the identification of new biomarkers for predicting disease and treatment outcome in classical Hodgkin lymphoma.
	Report
	Meeting report The challenges and hopes of personalized cancer medicine Wa Xian, Frank McKeon Genome Medicine 2011, 3:22 (19 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Genome Institute of Singapore and the Fritz Bender Stiftung joint meeting on 'Personalized Cancer Medicine: Towards Individualized Cancer Treatments', Singapore, 21-23 February 2011.