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DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma

Elke Schaeffeler*, Claus Hellerbrand, Anne T Nies, Stefan Winter, Stephan Kruck, Ute Hofmann, Heiko van der Kuip, Ulrich M Zanger, Hermann Koepsell and Matthias Schwab*

Genome Medicine 2011, 3:82 doi:10.1186/gm298

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Drug transporter regulation in tumors by DNA methylation

Oliver Zolk, Martin F Fromm Genome Medicine 2012, 4:10 (31 January 2012)

Oliver Zolk and Martin Fromm highlight a recent observation that uptake transporters for anticancer drugs are epigenetically regulated in hepatocellular carcinoma.