Genome Medicine | Volume 3 Issue 12

Advanced search

Submit a manuscript Register Follow us on

Explore journal

Articles

cover

	Volume 3 Issue 12
	Comment
	Research highlight Metabonomics adds a new dimension to fragile X syndrome Inge Heulens, Sien Braat, R Frank Kooy Genome Medicine 2011, 3:80 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Frank Kooy and colleagues highlight a recent study that provides new insights into the mechanisms underlying Fragile X syndrome through the metabolomics analysis of mouse models.
	Research highlight Predicting responses to sunitinib using single nucleotide polymorphisms: Progress and recommendations for future trials Ram N Ganapathi, Ronald M Bukowski Genome Medicine 2011, 3:79 (30 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ganapathi and Bukowski discuss the advances and pitfalls of a recent study of single nucleotide polymorphisms to predict the activity or toxicity of sunitinib for clear cell renal cell carcinoma.
	Review
	Review Health care providers and direct-to-consumer access and advertising of genetic testing in the United States Melanie F Myers Genome Medicine 2011, 3:81 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Melanie Myers reviews the impact of advertising and selling of genetic testing direct to consumers on health care providers and asks whether providers are ready to deal with this issue.
	Review Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model Corey S Martin, Akemi Moriyama, Leonard I Zon Genome Medicine 2011, 3:83 (29 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Martin, Moriyama and Zon review the advantages of zebrafish for studying early development of blood cells and highlight recent discoveries using this model that show clinical promise.
	Report
	Meeting report Pharmacogenomics and personalized medicine: the plunge into next-generation sequencing Mia Wadelius, Ana Alfirevic Genome Medicine 2011, 3:78 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mia Wadelius and Ana Alfirevic present highlights from the Cold Spring Harbor and the Wellcome Trust 2011 meeting on 'Pharmacogenomics and Personalized Medicine'.
	Research
	Research DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma Elke Schaeffeler, Claus Hellerbrand, Anne T Nies, Stefan Winter, Stephan Kruck, Ute Hofmann, Heiko van der Kuip, Ulrich M Zanger, Hermann Koepsell, Matthias Schwab Genome Medicine 2011, 3:82 (23 December 2011) Abstract \| Provisional PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary First evidence that decreased protein expression of the transporter SLC22A1 in hepatocellular carcinoma correlates with increased methylation of individual CpG sites.