Genome Medicine | Volume 3 Issue 10

Advanced search

Submit a manuscript Register Follow us on

Explore Genome Medicine

Articles

cover

	Volume 3 Issue 10
	Comment
	Musings Why have protein biomarkers not reached the clinic? Samir M Hanash Genome Medicine 2011, 3:66 (26 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Samir Hanash reflects on the reasons why there is a paucity of approved biomarkers for use in clinics, despite substantial advances in the understanding of the molecular basis of disease.
	Research highlight Predicting the pathogenesis of influenza from genomic response: a step toward early diagnosis Eric Bortz, Adolfo García-Sastre Genome Medicine 2011, 3:67 (24 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bortz and Garcia-Sastre highlight recent insights into the molecular events underlying host response to influenza virus that could allow early prediction of symptomatic or asymptomatic infection.
	Research highlight Personalized participatory medicine: sharing knowledge and uncertainty David Gurwitz, Jeantine E Lunshof Genome Medicine 2011, 3:69 (27 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary David Gurwitz and Jeantine Lunshof highlight recent research in Genome Medicine exploring the role of patients and doctors in personalizing breast cancer treatment on the basis of genotype information.
	Review
	Review Identification of cis-regulatory sequence variations in individual genome sequences Rebecca Worsley-Hunt, Virginie Bernard, Wyeth W Wasserman Genome Medicine 2011, 3:65 (10 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Wasserman and colleagues review existing methods and software for predicting the impact of cis-regulatory mutations on disease gene transcription and RNA processing.
	Review Transcriptomic analysis of pluripotent stem cells: insights into health and disease Jia-Chi Yeo, Huck-Hui Ng Genome Medicine 2011, 3:68 (27 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jia-Chi Yeo and Huck-Hui Ng review recent progress in understanding the transcriptional networks of pluripotent stem cells, and discuss how this knowledge has impacted translational medicine.
	Report
	Meeting report Genomics of common diseases: approaching the tipping point Alan F Wright Genome Medicine 2011, 3:70 (28 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Alan Wright reports highlights of the Wellcome Trust Scientific Conference 'The Genomics of Common Diseases 2011', emphasizing the limitations of GWAS and promise of new technologies.
	Research
	Research Pharmacogenetic testing affects choice of therapy among women considering tamoxifen treatment Wendy Lorizio, Hope Rugo, Mary S Beattie, Simone Tchu, Teri Melese, Michelle Melisko, Alan HB Wu, H Jeffrey Lawrence, Michele Nikoloff, Elad Ziv Genome Medicine 2011, 3:64 (4 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The choice of medication for breast cancer patients was changed after CYP2D6 genotyping, demonstrating for the first time that pharmacogenetics can shape clinical treatment decisions.