Genome Medicine | Volume 2 Issue 9

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	Volume 2 Issue 9
	Comment
	Commentary Biomarkers for late-onset neonatal sepsis Richard A Polin, Tara M Randis Genome Med 2010, 2:58 (6 September 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A recent study has identified apolipoprotein C-II and a variant of serum amyloid A as biomarkers for late-onset neonatal sepsis.
	Commentary New genetic links in eosinophilic esophagitis Jonathan M Spergel Genome Med 2010, 2:60 (7 September 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent research has identified of variants in the genes encoding thymic stromal lymphopoietin and its receptor as disease susceptibility markers for eosinophilic esophagitis and may point the way towards future treatments.
	Commentary From genotype to EEG endophenotype: a route for post-genomic understanding of complex psychiatric disease? Eco JC de Geus Genome Med 2010, 2:63 (7 September 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary While incorporating electroencephalography (EEG) into genetic-association studies is impractical, the description of EEG-derived brain endophenotypes can improve our understanding of the biological role of genetic variants found to be associated with complex psychiatric disease.
	Commentary From GWAS to the clinic: risk factors for intracranial aneurysms Ynte M Ruigrok, Gabriel JE Rinkel Genome Med 2010, 2:61 (10 September 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Discovering genetic risk factors for intracranial aneurysms may improve diagnosis and help to identify which aneurysms are most likely to rupture and therefore benefit from preventive treatment.
	Commentary Computational ecosystems for data-driven medical genomics Jonas S Almeida Genome Medicine 2010, 2:67 (20 September 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The problem of integration is becoming the central challenge for the life sciences; in the path towards personalized medicine, integrative computational infrastructures are a critical resource.
	Review
	Minireview Copy number variation in Parkinson's disease Mathias Toft, Owen A Ross Genome Med 2010, 2:62 (6 September 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Research into copy number variants involved in Parkinson's disease has provided insights into the pathogenic mechanisms behind the disorder and has potential to drive the development of novel therapeutics.
	Review Epigenetics of renal cell carcinoma: the path towards new diagnostics and therapeutics Mark R Morris, Eamonn R Maher Genome Med 2010, 2:59 (3 September 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Many genes are inactivated in renal cell carcinoma by methylation of their promoters; understanding the epigentics of this disease could lead to improved diagnostics and therapeutic approaches.
	Review Three periods of one and a half decade of ischemic stroke susceptibility gene research: lessons we have learned Anita Maasz, Bela Melegh Genome Med 2010, 2:64 (13 September 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Traditional genetic studies identified susceptibility genes for ischemic stroke but research is now focusing on genome-wide association studies and whole-genome sequencing techniques that should reveal novel genes associated with the condition and bring this information closer to application in clinical practice.
	Review Pharmacogenomic considerations in the opioid management of pain Paul J Jannetto, Nancy C Bratanow Genome Medicine 2010, 2:66 (15 September 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Pharmacogenomics can lead to more efficient opioid selection to minimize adverse drug reactions and improve patient outcome.
	Review Genetics of childhood and adolescent depression: insights into etiological heterogeneity and challenges for future genomic research Frances Rice Genome Medicine 2010, 2:68 (20 September 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Longitudinal studies of community and high-risk groups are required in order to better define phenotypic and etiological heterogeneity in childhood and adolescent depression and inform future genomic research into this condition.
	Report
	Meeting report Pharmacogenetics and pharmacogenomics: practical applications in routine medical practice Anke-Hilse Maitland-van der Zee, Ana Alfirevic Genome Medicine 2010, 2:69 (21 September 2010) Abstract \| Full text \| PDF \| PubMed
	Research
	Research Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme Kristian Ovaska, Marko Laakso, Saija Haapa-Paananen, Riku Louhimo, Ping Chen, Viljami Aittomäki, Erkka Valo, Javier Núñez-Fontarnau, Ville Rantanen, Sirkku Karinen, Kari Nousiainen, Anna-Maria Lahesmaa-Korpinen, Minna Miettinen, Lilli Saarinen, Pekka Kohonen, Jianmin Wu, Jukka Westermarck, Sampsa Hautaniemi Genome Medicine 2010, 2:65 (7 September 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Anduril, a computational framework that allows for rapid integration of heterogeneous molecular and clinical information, identifies Moesin as a novel gene associated with survival in glioblastoma multiforme and represents a valuable tool for systems analyses.
	Method Detection of DNA fusion junctions for BCR-ABL translocations by Anchored ChromPET Yoshiyuki Shibata, Ankit Malhotra, Anindya Dutta Genome Medicine 2010, 2:70 (22 September 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The Anchored ChromPET approach to define DNA breakpoints can identify chromosomal aberrations such as the BCR-ABL1 translocation, and is particularly useful for testing samples from which a good yield of RNA is difficult to obtain.