Table 4 |
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|
Proteins having some evidence (P < 0.05) of concentration difference between stroke cases and controls that are altered (P < 0.05) by postmenopausal hormone therapy |
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|
Stroke |
E+P |
E-alone |
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|
|
|
|
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|
Protein |
Description |
Log(base2) case vs control ratio |
P-valuea |
FDRa |
Log(base2) case vs control ratio |
P-valuea |
Log(base2) case vs control ratio |
P-valuea |
|
|
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|
APOA2 |
Apolipoprotein A-II |
-0.120 |
2.71e-05 |
0.00991 |
0.212 |
0.000532 |
0.302 |
1.75e-05 |
|
PPIA |
Peptidyl-prolyl cis-trans isomerase A |
0.194 |
7.68e-05 |
0.0141 |
0.381 |
0.00899 |
0.201 |
0.126 |
|
IGFBP4 |
Insulin-like growth factor-binding protein 4 |
0.409 |
0.000320 |
0.0391 |
0.179 |
0.102 |
0.511 |
0.000697 |
|
F2 |
Prothrombin (fragment) |
-0.0732 |
0.000702 |
0.0642 |
0.0633 |
0.00366 |
0.0282 |
0.138 |
|
C6 |
Complement component 6 precursor |
-0.140 |
0.00227 |
0.138 |
-0.123 |
0.00151 |
-0.171 |
0.000123 |
|
LILRA3 |
Leukocyte immunoglobulin-like receptor subfamily A member 3 |
0.316 |
0.00341 |
0.177 |
-0.237 |
0.00874 |
-0.281 |
0.000277 |
|
HPX |
Hemopexin |
-0.0448 |
0.00407 |
0.177 |
0.123 |
6.65e-05 |
0.117 |
0.000124 |
|
IGFBP6 |
Insulin-like growth factor-binding protein 6 |
0.667 |
0.00435 |
0.177 |
0.0868 |
0.235 |
0.207 |
0.0158 |
|
IGFBP2 |
Insulin-like growth factor-binding protein 2 |
0.480 |
0.00609 |
0.189 |
-0.420 |
0.00477 |
-0.287 |
0.0317 |
|
GC |
Vitamin D-binding protein |
-0.0532 |
0.00699 |
0.189 |
0.231 |
3.10e-06 |
0.237 |
2.75e-06 |
|
CADM1 |
Isoform 1 of cell adhesion molecule 1 |
-0.199 |
0.00762 |
0.189 |
-0.0139 |
0.875 |
0.180 |
0.0249 |
|
COL1A1 |
Collagen alpha-1(I) chain |
0.195 |
0.00826 |
0.189 |
-0.896 |
5.40e-07 |
-0.575 |
8.80e-05 |
|
COL6A3 |
Isoform 1 of collagen alpha-3(VI) chain |
0.828 |
0.0109 |
0.210 |
-0.197 |
0.00852 |
-0.0134 |
0.834 |
|
RNASE1 |
Ribonuclease pancreatic |
0.582 |
0.0143 |
0.243 |
0.0346 |
0.311 |
0.0953 |
0.0427 |
|
ITIH4 |
Isoform 2 of inter-alpha-trypsin inhibitor heavy chain H4 |
-0.238 |
0.0187 |
0.265 |
0.458 |
0.000733 |
0.374 |
0.00495 |
|
KLKB1 |
Plasma kallikrein |
-0.115 |
0.0202 |
0.270 |
0.252 |
0.00208 |
0.230 |
0.00187 |
|
B2M |
Beta-2-microglobulin |
0.0728 |
0.0280 |
0.310 |
0.208 |
0.00205 |
0.230 |
0.00110 |
|
SERPINC1 |
Antithrombin-III |
-0.0631 |
0.0312 |
0.325 |
-0.196 |
5.05e-06 |
-0.143 |
5.50e-05 |
|
FCN3 |
Isoform 1 of ficolin-3 |
0.132 |
0.0323 |
0.325 |
0.0351 |
0.0287 |
0.0357 |
0.0333 |
|
HGFAC |
Hepatocyte growth factor activator |
-0.592 |
0.0324 |
0.325 |
-0.191 |
0.0979 |
-0.308 |
0.00765 |
|
RBP4 |
Retinol-binding protein 4 |
0.0478 |
0.0346 |
0.325 |
0.167 |
0.000117 |
0.177 |
0.000262 |
|
CFHR5 |
Complement factor H-related 5 |
-0.0800 |
0.0348 |
0.325 |
0.179 |
0.000264 |
0.241 |
2.76e-05 |
|
PRDX2 |
Peroxiredoxin-2 |
-0.533 |
0.0361 |
0.325 |
0.691 |
0.0201 |
-0.0266 |
0.925 |
|
C8A |
Complement component C8 alpha chain |
-0.179 |
0.0373 |
0.325 |
-0.206 |
0.000163 |
-0.202 |
0.000121 |
|
FETUB |
Fetuin-B |
0.0662 |
0.0410 |
0.332 |
0.783 |
1.09e-09 |
0.741 |
1.02e-09 |
|
|
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|
aP-value = significance level for no difference in protein concentration; FDR = estimated false discovery rate. |
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|
Prentice et al. Genome Medicine 2010 2:48 doi:10.1186/gm169 |
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