Research
Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling
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* Corresponding author: Ross L Prentice rprentic@fhcrc.org
1 Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., Seattle, WA 98102, USA
2 Department of Pediatrics, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
3 Research and Development, AstraZeneca LP, 1971 Rockland Road, Wilmington, DE 19803, USA
4 Division of Endocrinology, Ohio State University, 198 McCampbell, 1581 Dodd Drive, Columbus, OH 43210, USA
5 WHI Project Office, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, USA
6 Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
7 Department of Preventive Medicine, University of Tennessee Health Sciences Center, 66 N. Pauline, Memphis, TN 38163, USA
8 Brown University, Memorial Hospital of Rhode Island, 111 Brewster Street, Pawtucket, RI 02860, USA
Genome Medicine 2010, 2:48 doi:10.1186/gm169
Published: 28 July 2010Additional files
Additional file 1:
Supplementary methods. Detailed methods for sample preparation, protein fractionation, and mass spectrometry analysis are described.
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Additional file 2:
Table S1. Baseline characteristics for women developing coronary heart disease (CHD) or stroke and for corresponding disease-free controls, drawn from the Women's Health Initiative Observational Study.
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Additional file 3:
Table S2. CHD case versus control log-transformed concentration ratios for all quantified proteins.
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Additional file 4:
Table S3. Stroke case versus control log(base2)-transformed concentration ratios for all quantified proteins.
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