Table 1

Established prostate cancer susceptibility alleles

dbSNP number

Chromosome

Gene^a

Risk allele^b

Study

rs1465618

2p21

THADA

A

Eeles et al. 2009 [21]

rs721048

2p15

EHBP1

A

Gudmundsson et al. 2008 [27]

rs12621278

2q31.1

ITGA6

A

Eeles et al. 2009 [21]

rs4857841

3q21.3

EEFSEC

A

Gudmundsson et al. 2009 [57]

rs12500426

4q22.3

PDLIM5

A

Eeles et al. 2009 [21]

rs17021918

4q22.3

PDLIM5

C

Eeles et al. 2009 [21]

rs7679673

4q24

FLJ20032

C

Eeles et al. 2009 [21]

rs9364554

6q25.3

SLC22A3

T

Eeles et al. 2008 [28]

rs10486567

7p15.2

JAZF1

G

Thomas et al. 2008 [26]

rs6465657

7q21.3

LMTK2

C

Eeles et al. 2008 [28]

rs1512268

8p21.2

NKX3-1

T

Eeles et al. 2009 [21]

rs12543663

8q24.21

C

Al Olama et al. 2009 [16]

rs10086908

8q24.21

T

Al Olama et al. 2009 [16]

rs1016343

8q24.21

T

Al Olama et al. 2009 [16]

rs13252298

8q24.21

A

Al Olama et al. 2009 [16]

rs6983561

8q24.21

C

Al Olama et al. 2009 [16]

rs16901979

8q24.21

A

Gudmundsson et al. 2007 [11]

rs16902094

8q24.21

G

Gudmundsson et al. 2009 [57]

rs445114

8q24.21

T

Gudmundsson et al. 2009 [57]

rs620861

8q24.21

C

Al Olama et al. 2009 [16]

rs6983267

8q24.21

G

Al Olama et al. 2009 [16]

rs1447295

8q24.21

A

Amundadottir et al. 2006 [9]

rs10993994

10q11.23

MSMB

T

Eeles et al. 2008 [28]

rs4962416

10q26.13

CTBP2

C

Thomas et al. 2008 [26]

rs7127900

11p15.5

A

Eeles et al. 2009 [21]

rs12418451

11q13.2

A

Zheng et al. 2009 [34]

rs11228565

11q13.2

A

Gudmundsson et al. 2009 [57]

rs10896449

11q13.2

G

Thomas et al. 2008 [26]

rs11649743

17q12

HNF1B

G

Sun et al. 2008 [30]

rs4430796

17q12

HNF1B

A

Gudmundsson et al. 2007 [11]

rs1859962

17q24.3

G

Gudmundsson et al. 2007 [11]

rs8102476

19q13.2

PPP1R14A

C

Gudmundsson et al. 2009 [57]

rs2735839

19q13.33

KLK3

A

Eeles et al. 2008 [28]

rs9623117

22q13.1

TNRC6B

C

Sun et al. 2009 [31]

rs5759167

22q13.2

BIK

G

Eeles et al. 2009 [21]

rs5945619

Xp11.22

NUDT11

C

Eeles et al. 2008 [28]

^aGenes within the linkage-disequilibrium block defined by the associated variant: BIK, BCL2-interacting killer; CTBP2, C-terminal binding protein 2 isoform 2; EEFSEC, elongation factor for selenoprotein translation; EHBP1, EH domain binding protein 1; FLJ20032, hypothetical protein LOC54790; HNF1B, hepatocyte nuclear factor 1 homeobox B; ITGA6, integrin alpha chain 6; JAZF1, juxtaposed with another zinc finger gene 1; KLK3, kallikrein 3; LMTK2, lemur tyrosine kinase 2; MSMB, β-microseminoprotein isoform a precursor; NKX3-1, NK3 transcription factor related locus 1; NUDT11, nudix-type motif 11; PDLIM5, PDZ and LIM domain 5 isoform d; PPP1R14A, protein phosphatase 1 regulatory inhibitor; SLC22A3, solute carrier family 22 member 3; SLC25A37, mitochondrial solute carrier protein; THADA, thyroid adenoma associated isoform 1; TNRC6B, trinucleotide repeat containing 6B isoform 2. ^bRisk alleles as defined from published data cited in the column.

Wiklund Genome Med 2010 2:45   doi:10.1186/gm166