Genome Medicine | Volume 2 Issue 7

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	Volume 2 Issue 7
	Comment
	Commentary Ethical issues raised by common copy number variants and single nucleotide polymorphisms of certain and uncertain significance in general medical practice Arthur L Beaudet Genome Medicine 2010, 2:42 (17 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Tests for single nucleotide polymorphisms and copy number variations generate differing ethical issues, but offering either test direct to consumers without guidance and interpretation from a physician or counselor raises further concerns.
	Commentary Models of the human metabolic network: aiming to reconcile metabolomics and genomics Philip W Kuchel Genome Medicine 2010, 2:46 (28 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The mainstream view of metabolism is being challenged, and creating a computer model of the metabolic network requires the development of new metabolite analysis techniques before it can become a reality.
	Commentary Piecing together the problems in diagnosing low-level chromosomal mosaicism Caroline Robberecht, Jean-Pierre Fryns, Joris Robert Vermeesch Genome Med 2010, 2:47 (29 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Low-level somatic chromosomal mosaicism can cause disease but is not easy to detect; genomic technologies are improving understanding and opening up new possibilities for diagnosis.
	Commentary Whole proteomes as internal standards in quantitative proteomics Shao-En Ong Genome Medicine 2010, 2:49 (30 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Pooling several proteomes labeled with stable isotopes yields an internal standard that can greatly increase the accuracy of quantitative proteomics.
	Review
	Review The influence of genomics and proteomics on the development of potential vaccines against meningococcal infection John E Heckels, Jeannette N Williams Genome Medicine 2010, 2:43 (22 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sequencing of genomes and availability of the corresponding protein databases, combined with sensitive proteomic techniques, have opened up exciting new avenues in meningococcal vaccine research.
	Review Functional genomics and rheumatoid arthritis: where have we been and where should we go? James N Jarvis, Mark Barton Frank Genome Medicine 2010, 2:44 (28 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gene expression profiling studies have enabled the development of signatures for patient classification and prediction of response to therapy in rheumatoid arthritis, and ongoing research into the transcriptome will likely bring further insight into our understanding of the disease.
	Review Prostate cancer genomics: can we distinguish between indolent and fatal disease using genetic markers? Fredrik Wiklund Genome Med 2010, 2:45 (29 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary While genome-wide association studies have revealed genetic variants associated with prostate cancer, there is a need for further research into genetic factors able to discriminate between indolent and fatal forms of the disease in order to improve clinical management.
	Research
	Research Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling Ross L Prentice, Sophie Paczesny, Aaron Aragaki, Lynn M Amon, Lin Chen, Sharon J Pitteri, Martin McIntosh, Pei Wang, Tina Buson Busald, Judith Hsia, Rebecca D Jackson, Jacques E Rossouw, JoAnn E Manson, Karen Johnson, Charles Eaton, Samir M Hanash Genome Medicine 2010, 2:48 (28 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In-depth proteome analysis of samples from postmenopausal women identifies the level of beta-2 microglobulin and insulin-like growth factor binding protein as biomarkers for risk of coronary heart disease and stroke respectively.