Table 2 |
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|
Relationship between clinical and biochemical characteristics and histological groups in infants with biliary atresia |
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|
Patient characteristic |
Inflammatory subtype, N = 14 |
Fibrosing subtype, N = 17 |
Total, N = 31a |
P-valueb |
|
|
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|
Sex, N (%) |
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|
Female |
5 (36) |
6 (35) |
11 (35) |
1.0 |
|
Male |
9 (64) |
11 (65) |
20 (65) |
|
|
Race, N (%) |
||||
|
White |
11 (79) |
16 (94) |
27 (87) |
1.0 |
|
Black |
0 (0) |
0 (0) |
0 (0) |
1.0 |
|
Asian |
2 (14) |
1 (6) |
3 (10) |
1.0 |
|
Other |
1 (7) |
0 (0) |
1 (3) |
1.0 |
|
Ethnicity, N (%) |
||||
|
Hispanic |
1 (7) |
2 (12) |
3 (10) |
1.0 |
|
Nonhispanic |
13 (93) |
15 (88) |
28 (90) |
|
|
Age in days, median (25-75%) |
63 (55-65) |
66 (51-77) |
63 (51-73) |
0.3 |
|
Clinical type |
||||
|
BASM N (%) |
1 (7) |
1 (6) |
2 (7) |
1.0 |
|
Perinatal N (%) |
13 (93) |
16 (94) |
29 (93) |
|
|
Mean CB at diagnosisc |
5.1 ± 1.6 |
5.8 ± 2.5 |
5.6 ± 2.2 |
0.5 |
|
Mean ALT at diagnosisc |
196 ± 150 |
192 ± 120 |
194 ± 136 |
1.0 |
|
Mean CB at 3 months after HPEc |
2.3 ± 3.7 |
3.0 ± 3.5 |
2.6 ± 3.6 |
0.7 |
|
Weight Z-score at 6 months after HPEc |
-1.1 ± 0.9 |
-1.8 ± 1.9 |
-1.4 ± 1.4 |
0.3 |
|
Presence of cholangitis, N (%) |
5 (56) |
10 (59) |
15 (58) |
1.0 |
|
Presence of ascites, N (%) |
4 (36) |
9 (53) |
13 (47) |
0.7 |
|
|
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|
aSixteen subjects from the cohort of 47 patients are not included because the differences in histological scores for inflammation and fibrosis were zero. bP-values denote levels of statistical differences between inflammation and fibrosis groups. cMean ± standard deviation. ALT, alanine aminotransferases; BASM, biliary atresia splenic malformation (polysplenia or asplenia); CB, conjugated bilirubin; HPE, hepatoportoenterostomy. |
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|
Moyer et al. Genome Medicine 2010 2:33 doi:10.1186/gm154 |
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