Likelihood ratios for genome medicine
1 Department of Pediatrics and the Department of Medicine, Stanford University School of Medicine, 251 Campus Drive, MS-5415, Stanford, CA 94305-5479, USA
2 Biomedical Informatics Training Program, Stanford University School of Medicine, 251 Campus Drive, Stanford, CA 94305, USA
3 Lucile Packard Children's Hospital, 725 Welch Road, Palo Alto, CA 94304, USA
Genome Medicine 2010, 2:30 doi:10.1186/gm151Published: 17 May 2010
Patients are beginning to present to healthcare providers with the results of high-throughput individualized genotyping, and interpreting these results in the context of the explosive growth of literature linking individual variants with disease may seem daunting. However, we suggest that results of a personal genomic analysis may be viewed as a panel of many tests for multiple diseases. By using well-established methods of evidence based medicine, these very many parallel tests may be combined using likelihood ratios to report a post-test probability of disease for use in patient assessment.