Genome Medicine | Volume 2 Issue 5

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	Volume 2 Issue 5
	Comment
	Commentary Likelihood ratios for genome medicine Alexander A Morgan, Rong Chen, Atul J Butte Genome Medicine 2010, 2:30 (17 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Using well-established methods of evidence based medicine, the results of parallel genomic analyses may be combined using likelihood ratios to report a post-test probability of disease for use in patient assessment.
	Review
	Minireview Schizophrenic: forever young? Benedetta Frida Baldi, Christine Hoyer, Nicolas Le Novère Genome Medicine 2010, 2:32 (18 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent microarray analysis and prevalent hypotheses of schizophrenia suggest that the schizophrenic brain might resemble a juvenile brain.
	Minireview The role of complex genomic alterations in neuroblastoma risk estimation Matthias Fischer, Frank Berthold Genome Medicine 2010, 2:31 (19 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Global genomic profiles could help define the prognosis of neuroblastoma patients.
	Review Retinitis pigmentosa and allied conditions today: a paradigm of translational research Carmen Ayuso, Jose M Millan Genome Medicine 2010, 2:34 (27 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Knowledge of genes and pathways involved in photoreceptor degeneration underlying retinitis pigmentosa is the first step in implementing correct clinical management, and possible prevention or therapy.
	Review Novel genes for QTc interval. How much heritability is explained, and how much is left to find? Yalda Jamshidi, Ilja M Nolte, Timothy D Spector, Harold Snieder Genome Medicine 2010, 2:35 (27 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary QTc interval is a complex trait with prognostic relevance for cardiovascular mortality, and about 10% of the heritability of this trait can be identified in a genetic risk model examining significant single nucleotide polymorphisms.
	Research
	Research Staging of biliary atresia at diagnosis by molecular profiling of the liver Katie Moyer, Vivek Kaimal, Cristina Pacheco, Reena Mourya, Huan Xu, Pranavkumar Shivakumar, Ranajit Chakraborty, Marepalli Rao, John C Magee, Kevin Bove, Bruce J Aronow, Anil G Jegga, Jorge A Bezerra Genome Medicine 2010, 2:33 (13 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A molecular signature for biliary atresia classifies samples into inflammation or fibrosis stages at diagnosis and will be valuable for personalized clinical management of this disease.