Table 3

Predicted biological functions from Ingenuity Pathways Analysis

P-value

Number of genes

Genes


Diseases and disorders

Neurological disease

1.38E-03 to 1.89E-02

8

UCHL1,ATF3,NDP,TUBB2C,KIF1B,TUBB2A,MST1,BCL2

Inflammatory disease

2.51E-03 to 2.11E-02

16

IL6ST,ADM,TUBB2C,IL32,PIK3R1,TUBB2A,EIF1,ALOX5AP,MMP10,DUSP2,BCL2,GNAI2,HSPA8,FUT8,LDLR,AHNAK

Skeletal and muscular disorders

2.71E-03 to 1.89E-02

16

IL6ST,ADM,COL6A2,TUBB2C,IL32,TUBB2A,ALOX5AP,MMP10,LARGE,DUSP2,BCL2,GNAI2,HSPA8,CEP290,BMI1,AHNAK

Molecular and cellular functions

Lipid metabolism

1.19E-04 to 2.51E-02

13

ADM,IL6ST,ABCG5,ABHD5,IL32,PIK3R1,ALOX5AP,BCL2,GNAI2,IFRD1,LDLR,PRKAR2B,PITPNC1

Molecular transport

1.19E-04 to 2.51E-02

12

IL6ST,IFRD1,HSPA8,GNAI2,ABHD5,ABCG5,LDLR,PIK3R1,IL32,PITPNC1,ALOX5AP,BCL2

Small molecule biochemistry

1.19E-04 to 2.51E-02

17

IL6ST,ADM,AMPD3,ABCG5,ABHD5,PIK3R1,ASS1,IL32,ALOX5AP,BCL2,IFRD1,GNAI2,BCAT1,LDLR,PITPNC1,GOT1,GLDC

Cellular development

1.32E-04 to 2.42E-02

13

IL6ST,ATF3,PIK3R1,ID3,BCL2,IGLL1,IFRD1,ELF3,BMI1,PRKAR2B,PLK2,LAMA1,PLAC8

Cell death

2.36E-04 to 1.89E-02

14

IL6ST,ADM,ATF3,DDIT4,PIK3R1,NCK1,PSIP1,SH3BP5,ID3,BCL2,PRKAR2B,BMI1,PLK2,PLAC8

Canonical pathways

Nitric oxide signaling

1.07E-02

3/90

CACNA1E,PRKAR2B,PIK3R1

VEGF signaling

1.47E-02

3/92

PIK3R1,EIF1,BCL2

Amyotrophic lateral sclerosis signaling

1.88E-02

3/108

CACNA1E,PIK3R1,BCL2

Toxicity list

Hormone receptor regulated cholesterol metabolism

4.96E-02

1/8

LDLR


IPA of significant disorders, molecular and cellular functions, canonical pathways, and toxicity genes that are strongly associated with 94 differentially expressed potential target genes of the miRNAs (log2 ratio ≥± 0.4). The Fisher's exact P-values and the number of genes for each top biological function are listed. VEGF, vascular endothelial growth factor.

Sarachana et al. Genome Medicine 2010 2:23   doi:10.1186/gm144

Open Data