Table 2

Ingenuity Pathways Analysis biological functions and pathways associated with potential targets for significantly differentially expressed miRNAs

miRNA

Biological functions/pathways of the miRNA targets (P-value) [number of genes]*


hsa-miR-182

N (1.18E-03 to 3.86E-02) [59], E (1.49E-03 to 3.70E-02) [14]

hsa-mir-136

G (1.60E-04 to 3.46E-02) [10], A (6.33E-03) [8], E (3.50E-03 to 3.46E-02) [21]

hsa-miR-518a

N (7.24E-03 to 4.89E-02) [50], E (8.57E-05 to 4.44E-02) [20]

hsa-mir-153-1

N (1.02E-05 to 2.24E-02) [28], G (6.37E-04 to 1.53E-02) [13]

hsa-miR-520b

N (2.66E-03 to 4.44E-02) [15],E (8.13E-04 to 4.44E-02) [28]

hsa-miR-455

N (2.03E-03 to 4.51E-02) [83], E (1.06E-03 to 4.51E-02) [42]

hsa-miR-326

S (6.24E-04 to 3.99E-02) [28]

hsa-miR-199b

N (8.24E-04 to 4.23E-02) [31], E (6.04E-03 to 4.23E-02) [21], S (5.23E-03 to 4.23E-02) [11]

hsa-miR-211

N (7.78E-05 to 2.99E-02) [15],I (6.23E-04 to 2.99E-02) [19]

hsa-mir-132

N (2.01E-03 to 4.48E-02) [19], G (2.01E-03 to 4.48E-02) [23], E (2.01E-03 to 4.48E-02) [28]

hsa-miR-495

N (6.09E-04 to 4.02E-02) [48], G (1.62E-03 to 4.02E-02) [10], E (2.51E-04 to 4.02E-02) [24]

hsa-mir-16-2

N (8.75E-05 to 4.45E-02) [13], E (1.06E-03 to 4.45E-02) [24], S (1.58E-03 to 4.45E-02) [17], Es (4.86E-02) [9]

hsa-miR-190

N (6.63E-04 to 3.86E-02) [39], G (2.15E-03 to 3.86E-02) [12], E (3.83E-04 to 4.15E-02) [25]

hsa-miR-219

N (1.08E-03 to 4.34E-02) [87], E (1.88E-03 to 4.34E-02) [11]

hsa-miR-148b

N (6.54E-04 to 4.63E-02) [27], G (3.81E-04 to 4.63E-02) [27]

hsa-miR-189

N (1.57E-03 to 3.76E-02) [23}, E (1.57E-03 to 3.76E-02) [19]

hsa-miR-133b

E (7.84E-04 to 2.56E-02) [17]

hsa-mir-106b

N (1.37E-03 to 4.41E-02) [21], G (1.01E-02 to 4.23E-02) [33], I (1.54E-03 to 4.38E-02) [18]

hsa-miR-367

N (1.35E-03 to 4.37E-02) [20], G (1.33E-03 to 4.37E-02) [11]

hsa-miR-139

G (1.37E-03 to 4.02E-02) [19], E (1.61E-03 to 4.02E-02) [21]

hsa-miR-186

N (9.62E-04 to 3.11E-02) [27],E (2.83E-03 to 3.11E-02) [14], S (9.62E-04 to 3.11E-02) [17], Es (1.82E-02) [8]

hsa-mir-93

N (2.67E-04 to 4.33E-02) [36], I (4.47E-04 to 4.33E-02) [35]

hsa-miR-30c

N (9.85E-05 to 4.21E-02) [40], E (3.31E-04 to 4.21E-02) [25]

hsa-miR-205

N (1.40E-03 to 3.75E-02) [9],S (1.19E-04 to 3.75E-02) [23]

hsa-miR-346

I (8.61E-04 to 3.03E-02) [56]

hsa-miR-519c

G (7.42E-04 to 4.76E-02) [81], N (6.58E-03 to 4.71E-02) [25]

hsa-miR-25

N (1.04E-04 to 3.61E-02) [39], Es (3.95E-02) [8]

hsa-mir-186

N (9.62E-04 to 3.11E-02) [27],E (2.83E-03 to 3.11E-02) [14], S (9.62E-04 to 3.11E-02) [17],Es (1.82E-02) [8]

hsa-miR-23a

N (1.69E-03 to 4.11E-02) [81], S (8.70E-04 to 4.11E-02) [62]

hsa-miR-342

N (6.49E-04 to 4.11E-02) [15], E (2.13E-03 to 4.11E-02) [12], S (6.49E-04 to 4.11E-02) [15]

hsa-miR-23b

N (4.31E-05 to 4.01E-02) [87], S (3.71E-03 to 4.01E-02) [60], E (4.68E-03 to 4.01E-02) [20]

hsa-miR-195

N (4.59E-03 to 4.04E-02) [74], Es (1.12E-02) [10]

hsa-miR-23b

N (4.31E-05 to 4.01E-02) [87], S (3.71E-03 to 4.01E-02) [60], E (4.68E-03 to 4.01E-02) [20]

hsa-miR-451

S (2.99E-04 to 2.43E-02) [29]

hsa-miR-376a

N (1.62E-03 to 3.88E-02) [23], E (1.62E-03 to 3.10E-02) [10], S (1.17E-04 to 4.02E-02) [32], C (4.71E-03) [5]

hsa-miR-191

N (2.53E-04 to 4.62E-02) [34], E (1.87E-03 to 3.93E-02) [12]

hsa-miR-524-3p

N (3.44E-04 to 4.47E-02) [66]

hsa-miR-194

N (8.47E-03 to 3.86E-02) [24]

hsa-miR-29b

S (1.97E-05 to 2.91E-02) [41], C (1.63E-03) [6]

hsa-miR-107

G (4.81E-04 to 4.13E-02) [46], E (1.27E-03 to 4.13E-02), N (1.70E-03 to 4.13E-02) [16]

hsa-miR-103

G (1.31E-03 to 4.27E-02) [49], E (2.01E-04 to 4.27E-02), S (3.03E-03 to 4.27E-02) [23], N (1.82E-03 to 4.27E-2) [35]

hsa-miR-185

N (8.16E-04 to 3.75E-02) [26]


IPA analysis of potential target genes for each of the significantly differentially expressed miRNAs revealed biological functions and pathways associated with the target genes. P-values calculated from Fisher's exact test for each function are listed in parenthesis; the number of genes involved in each biological function or pathway is listed in square brackets. The functions are described as: A, androgen and estrogen metabolism; C, circadian rhythm signaling; E, embryonic development; Es, estrogen receptor signaling; G, gastrointestinal diseases/digestive system development and functions; I, inflammatory diseases; N, neurological diseases/nervous system development and functions; S, skeletal and muscular disorders/skeletal and muscular system development and functions.

Sarachana et al. Genome Medicine 2010 2:23   doi:10.1186/gm144

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