Genome Medicine | Volume 2 Issue 4

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	Volume 2 Issue 4
	Comment
	Commentary Carrier detection in childhood: a need for policy reform Lainie Ross Genome Medicine 2010, 2:25 (22 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Minors are not usually screened for disease carrier status, but their status can affect their health and may inform their reproductive decisions.
	Commentary The public health utility of genome-wide association study results for smoking behavior Helena Furberg, Jamie Ostroff, Caryn Lerman, Patrick F Sullivan Genome Medicine 2010, 2:26 (27 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary To reduce the burden of smoking on society, multidiciplinary research is needed to help translate genome-wide association studies for smoking behavior to the clinic.
	Review
	Minireview Trinucleotide repeats: triggers for genomic disorders? Piotr Kozlowski, Krzysztof Sobczak, Wlodzimierz J Krzyzosiak Genome Medicine 2010, 2:29 (30 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The involvement of long TGG repeat tracts in a recurrent chromosome microdeletion has highlighted a potential role for trinucleotide repeats in genomic disorders, and the need for further research into the mechanisms behind this type of rearrangements.
	Review Progress in the use of RNA interference as a therapy for chronic hepatitis B virus infection Marc S Weinberg, Patrick Arbuthnot Genome Medicine 2010, 2:28 (28 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The development of RNA interference to treat Hepatitis B virus infection is progressing rapidly but further refinement is still needed for clinical applications.
	Review Genetic and epigenetic insights into fetal alcohol spectrum disorders Michèle Ramsay Genome Medicine 2010, 2:27 (28 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The detrimental effects of alcohol on embryonic development, which can last throughout life and into following generations, are probably mediated by epigenetic processes.
	Research
	Research Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines Tewarit Sarachana, Rulun Zhou, Guang Chen, Husseini K Manji, Valerie W Hu Genome Medicine 2010, 2:23 (7 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary 43 microRNAs with target genes associated with autism are dysregulated in samples from patients with this condition, suggesting that microRNAs contribute to the gene expression alterations and consequently the physiological abnormalities underlying autistic spectrum disorders.
	Correspondence
	Correspondence Locus Reference Genomic sequences: an improved basis for describing human DNA variants Raymond Dalgleish, Paul Flicek, Fiona Cunningham, Alex Astashyn, Raymond E Tully, Glenn Proctor, Yuan Chen, William M McLaren, Pontus Larsson, Brendan W Vaughan, Christophe Béroud, Glen Dobson, Heikki Lehväslaiho, Peter EM Taschner, Johan T den Dunnen, Andrew Devereau, Ewan Birney, Anthony J Brookes, Donna R Maglott Genome Medicine 2010, 2:24 (15 April 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Locus Reference Genomic sequence format provides a single record containing a reference DNA sequence and all relevant transcripts and protein sequences, which should reduce errors in reporting and lead to improved communication about variants involved in disease.