Genome Medicine | Volume 2 Issue 3

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	Volume 2 Issue 3
	Comment
	Commentary The need for medical education reform: genomics and the changing nature of health information Elizabeth A Nelson, Amy L McGuire Genome Medicine 2010, 2:18 (17 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Medical education reform is necessary to ensure future doctors are ready for the challenges of shifting patient expectations, the handling of increasing amounts of data and the translation of genomic information into personalized care.
	Commentary Tailoring the process of informed consent in genetic and genomic research Charles N Rotimi, Patricia A Marshall Genome Medicine 2010, 2:20 (24 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The complexities of conducting genomic research highlight the need to tailor informed consent processes to individual studies and populations in order to address not only scientific but also cultural and social factors.
	Review
	Minireview High-throughput analysis of chromosome translocations and other genome rearrangements in epithelial cancers Scott Newman, Paul AW Edwards Genome Medicine 2010, 2:19 (17 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Large-scale sequencing using the 'paired end' strategy shows that the cancer genome has many more rearrangements than previously thought
	Minireview Simulating gene-environment interactions in complex human diseases Bo Peng Genome Medicine 2010, 2:21 (23 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Novel mathematical model and computer programs allow the simulation of gene-environment interactions in complex human diseases and may pave the way for future applications to real-world genetic samples.
	Review Proteomic and metabolomic strategies to investigate HIV-associated neurocognitive disorders Gurudutt Pendyala, Howard S Fox Genome Medicine 2010, 2:22 (30 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The combination of established proteomic techniques and novel metabolomic approaches holds promise for the discovery of novel protein biomarkers for HIV-associated neurocognitive disorders.
	Research
	Research A whole genome association study of mother-to-child transmission of HIV in Malawi Bonnie R Joubert, Ethan M Lange, Nora Franceschini, Victor Mwapasa, Kari E North, Steven R Meshnick, the NIAID Center for HIV/AIDS Vaccine Immunology Genome Medicine 2010, 2:17 (1 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mother-to-child HIV transmission in Malawian infants is associated with nine single nucleotide polymorphisms in six genes with roles in pregnancy, development, innate immunity and HIV-protein interaction.
	Database Collaboratively charting the gene-to-phenotype network of human congenital heart defects Roland Barriot, Jeroen Breckpot, Bernard Thienpont, Sylvain Brohée, Steven Van Vooren, Bert Coessens, Leon-Charles Tranchevent, Peter Van Loo, Marc Gewillig, Koenraad Devriendt, Yves Moreau Genome Medicine 2010, 2:16 (1 March 2010) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology \| Editor’s summary The development of a specialized portal for collaborative annotation and analysis of gene-phenotype networks in congenital heart defects using a Wiki platform highlights this technology’s potential for systems biology studies of other complex biological processes.