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Resolution: standard / high Figure 4.
Relationship between narrow sense (additive)
and broad sense heritability on the risk scale for different disease prevalences (K). From simulations of a single population of 106 individuals, with calculated as 4(λOG - 1)K/(1-K) where λOG is the recurrence risk of disease in grandchildren of affected grandparents and calculated from Equation 2.
Wray and Goddard Genome Medicine 2010 2:10 doi:10.1186/gm131 |