Genome Medicine | Volume 2 Issue 2

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	Volume 2 Issue 2
	Comment
	Commentary Developmental origins of health and disease: reducing the burden of chronic disease in the next generation Peter D Gluckman, Mark A Hanson, Murray D Mitchell Genome Medicine 2010, 2:14 (24 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary There is an unwillingness among public health decision makers to implement approaches based on evidence that environmental factors in early life can affect disease vulnerability in later life.
	Review
	Review Inversion variants in the human genome: role in disease and genome architecture Lars Feuk Genome Med 2010, 2:11 (12 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary While paired-end sequencing approaches have allowed the identification and mapping of inversions across the human genome, further characterization of inversion variants is required to advance our understanding of human variation and genome dynamics.
	Review Non-coding RNAs: a key to future personalized molecular therapy? Marco Galasso, Maria Elena Sana, Stefano Volinia Genome Medicine 2010, 2:12 (18 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Non-coding RNAs such as microRNAs and small nucleolar RNAs are implicated in human diseases ranging from cancer to neurodegenerative and metabolic diseases and offer new avenues for the development of non-invasive diagnostics and molecular therapies.
	Review Coping with antibiotic resistance: contributions from genomics Gian Rossolini, Maria Thaller Genome Medicine 2010, 2:15 (25 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bacterial genomics is helping to tackle antibiotic resistance by identifying new targets and increasing our understanding of resistance mechanisms.
	Report
	Meeting report Pharmacogenomics and personalized medicine: lost in translation? Jean-Sébastien Hulot Genome Medicine 2010, 2:13 (22 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A report on the Joint Cold Spring Harbor/Wellcome Trust Conference 'Pharmacogenomics & Personalized Medicine', Hinxton, UK, 12-15 September 2009.
	Research
	Research Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes Iain J Gallagher, Camilla Scheele, Pernille Keller, Anders R Nielsen, Judit Remenyi, Christian P Fischer, Karim Roder, John Babraj, Claes Wahlestedt, Gyorgy Hutvagner, Bente K Pedersen, James A Timmons Genome Medicine 2010, 2:9 (1 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Muscle mRNA expression is invariant with respect to diabetes status, but coordinated changes in numerous microRNAs may control protein abundance and affect skeletal muscle insulin resistance, a critical component of the disease.
	Research Multi-locus models of genetic risk of disease Naomi R Wray, Michael E Goddard Genome Medicine 2010, 2:10 (2 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The widely accepted unconstrained multiplicative model which combines genome wide association data for overall risk calculation is not realistic, while other models more compatible with the data are indistinguishable using currently available observed parameters.