Genome Medicine | Volume 2 Issue 12

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	Volume 2 Issue 12
	Comment
	Commentary Overcoming bias and systematic errors in next generation sequencing data Margaret A Taub, Hector Corrada Bravo, Rafael A Irizarry Genome Medicine 2010, 2:87 (10 December 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary High-throughput sequencing presents many challenges when it comes to avoiding bias and batch effects, and clinical applications will only be feasible when these issues can be overcome.
	Commentary Gene expression deconvolution in clinical samples Yingdong Zhao, Richard Simon Genome Med 2010, 2:93 (29 December 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Methods for deconvoluting gene expression profiles from heterogenous cell mixtures could be useful for analysis of clinical samples.
	Review
	Review Protein biomarkers in cystic fibrosis research: where next? Sally H Pattison, J Stuart Elborn Genome Medicine 2010, 2:88 (16 December 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Proteomics has considerably advanced our understanding of cystic fibrosis, and rapid advancements are expected to augment its future contribution towards improving the prognosis of patients with cystic fibrosis.
	Review Does consuming isoflavones reduce or increase breast cancer risk? Maria Bondesson, Jan-Ake Gustafsson Genome Medicine 2010, 2:90 (21 December 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Different epidemiological and animal studies differ on whether consumption of phytoestrogens, such as isoflavones, increases or decreases the risk of breast cancer.
	Review Information from cochlear potentials and genetic mutations helps localize the lesion site in auditory neuropathy Rosamaria Santarelli Genome Med 2010, 2:91 (22 December 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A review of genetically based auditory neuropathies and their proposed underlying molecular mechanisms.
	Review New insights into the roles of microRNAs in drug addiction and neuroplasticity Jean-Luc Dreyer Genome Medicine 2010, 2:92 (23 December 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Specific miRNAs have emerged as key regulators leading to addiction, and they could serve as potential targets for therapeutic intervention for addiction and related brain disorders.
	Report
	Meeting report Report of the 60th annual meeting of the American Society of Human Genetics: several steps toward discoveries Leonid Padyukov Genome Medicine 2010, 2:89 (21 December 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of the 60th annual meeting of the American Society of Human Genetics in Washington, DC, USA, 2-6 November 2010.