A correction to: Bonnie R Joubert, Ethan M Lange, Nora Franceschini, Victor Mwapasa, Kari E North, Steven R Meshnick andthe NIAID Center for HIV/AIDS Vaccine Immunology. A whole genome association study of mother-to-child transmission of HIV in Malawi. Genome Medicine 2010, 2:17.
We wish to report some corrections to our study , none of which alters the interpretation of the data or the conclusions drawn. After publication of this work we noted that the sample size required further clarification.
A total of 246 infants (114 cases, 132 controls; 116 males, 121 females, 9 with imputed gender) passed laboratory quality control. Statistical quality control removed 15 individuals for low genotyping, resulting in a total of 231 individuals (103 cases, 128 controls; 114 males, 117 females). Of the 655,352 SNPs tested, 68,297 failed statistical quality control due to HWE P < 0.001 in the controls (N = 431), low genotyping rate (N = 21,589), or for MAF < 0.01 (N = 53,477), where some overlap of SNPs across exclusion criteria existed. Results were presented for 587,055 SNPs.
Additional data files
Additional file 1. A Word document giving effect estimates for top SNPs of interest, by mode of transmission. The data provided represent the genome-wide association analysis by mode of HIV transmission.
Format: DOCX Size: 17KB Download file
Additional file 2. A Word document giving effect estimates for SNPs near or within genes associated with HIV/AIDS. The data provided represent the genome-wide association analysis for specific regions that have previously demonstrated association with HIV/AIDS, described in the Introduction section.
Format: DOCX Size: 73KB Download file
Joubert Bonnie R, Lange Ethan M, Franceschini Nora, Mwapasa Victor, North Kari E, Meshnick Steven R, the NIAID Center for HIV/AIDS Vaccine Immunology: A whole genome association study of mother-to-child transmission of HIV in Malawi.