Open Access Correction

Correction: A whole genome association study of mother-to-child transmission of HIV in Malawi

Bonnie R Joubert1*, Ethan M Lange2,3,4, Nora Franceschini1, Victor Mwapasa5, Kari E North1,4, Steven R Meshnick1 and the NIAID Center for HIV/AIDS Vaccine Immunology

Author Affiliations

1 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA

2 Department of Genetics, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA

3 Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA

4 Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA

5 College of Medicine, University of Malawi, Blantyre, Malawi

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Genome Medicine 2010, 2:76 doi:10.1186/gm197


The electronic version of this article is the complete one and can be found online at: http://genomemedicine.com/content/2/10/76


Received:1 October 2010
Accepted:11 October 2010
Published:11 October 2010

© 2010 Joubert et al.;licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A correction to: Bonnie R Joubert, Ethan M Lange, Nora Franceschini, Victor Mwapasa, Kari E North, Steven R Meshnick andthe NIAID Center for HIV/AIDS Vaccine Immunology. A whole genome association study of mother-to-child transmission of HIV in Malawi. Genome Medicine 2010, 2:17.

Correction

We wish to report some corrections to our study [1], none of which alters the interpretation of the data or the conclusions drawn. After publication of this work we noted that the sample size required further clarification.

Results

A total of 246 infants (114 cases, 132 controls; 116 males, 121 females, 9 with imputed gender) passed laboratory quality control. Statistical quality control removed 15 individuals for low genotyping, resulting in a total of 231 individuals (103 cases, 128 controls; 114 males, 117 females). Of the 655,352 SNPs tested, 68,297 failed statistical quality control due to HWE P < 0.001 in the controls (N = 431), low genotyping rate (N = 21,589), or for MAF < 0.01 (N = 53,477), where some overlap of SNPs across exclusion criteria existed. Results were presented for 587,055 SNPs.

Additional data files

Additional data files 1 and 2 containing the corrected data are available online with this article.

Additional file 1. A Word document giving effect estimates for top SNPs of interest, by mode of transmission. The data provided represent the genome-wide association analysis by mode of HIV transmission.

Format: DOCX Size: 17KB Download fileOpen Data

Additional file 2. A Word document giving effect estimates for SNPs near or within genes associated with HIV/AIDS. The data provided represent the genome-wide association analysis for specific regions that have previously demonstrated association with HIV/AIDS, described in the Introduction section.

Format: DOCX Size: 73KB Download fileOpen Data

References

  1. Joubert Bonnie R, Lange Ethan M, Franceschini Nora, Mwapasa Victor, North Kari E, Meshnick Steven R, the NIAID Center for HIV/AIDS Vaccine Immunology: A whole genome association study of mother-to-child transmission of HIV in Malawi.

    Genome Medicine 2010, 2:17. PubMed Abstract | PubMed Central Full Text OpenURL

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