Genome Medicine


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Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia

Nathan A Stephens1, Iain J Gallagher2*, Olav Rooyackers3, Richard J Skipworth1, Ben H Tan1, Troels Marstrand4, James A Ross1, Denis C Guttridge5, Lars Lundell3, Kenneth C Fearon1 and James A Timmons2,7,6*

Author Affiliations

1 Department of Clinical and Surgical Sciences (Surgery), School of Clinical Sciences and Community Health, University of Edinburgh, EH16 4SB, UK

2 Translational Biomedicine, Heriot-Watt University, Edinburgh, EH14 4AS, UK

3 Department of Anaesthesiology and Intensive Care, and Department of Surgery, Karolinska University Hospital, 14186, Huddinge, Sweden

4 Department of Biology and Biotech Research and Innovation Centre, Ole Maaloes Vej 5, University of Copenhagen, DK-2200, Denmark

5 Division of Human Cancer Genetics, Ohio State University Medical Center, Columbus, OH 43210, USA

6 Lifestyle Research Group, The Royal Veterinary College, 4 Royal College Street, University of London, NW1 0TU, UK

7 Centre for Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej, DK-2200, Denmark

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Genome Medicine 2010, 2:1 doi:10.1186/gm122

Published: 15 January 2010

Additional files

Additional file 1:

Primers used in the study, genes associated with systemic inflammation and data on autophagy pathway genes.

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Additional file 2:

Genes associated with weight loss or systemic inflammation in cancer cachexia.

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Additional file 3:

Figures and figure legends for supplementary figures referred to in the text.

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