Genome Medicine | Volume 2 Issue 1

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	Volume 2 Issue 1
	Comment
	Commentary The 1000 Genomes Project: new opportunities for research and social challenges Marc Via, Christopher Gignoux, Esteban Burchard Genome Medicine 2010, 2:3 (21 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Safeguarding against ethical and privacy concerns will help clinical research to benefit from the 1000 Genomes Project.
	Musings Musings on genome medicine: Hepatitis C David G Nathan, Stuart H Orkin Genome Medicine 2010, 2:4 (27 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent advances in our understanding of the genetics of response to interferon treatment are intriguing, but further research is necessary before we can achieve a true cure for hepatitis C.
	Review
	Review Genomic variants associated with primary biliary cirrhosis Carlo Selmi, Natalie J Torok, Andrea Affronti, M Eric Gershwin Genome Medicine 2010, 2:5 (26 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Association of primary biliary cirrhosis with many genetic variants has not greatly improved our understanding of the disease, but epigenomic and microRNA research may provide more answers.
	Review Recent advances in the genetics of language impairment Dianne F Newbury, Simon E Fisher, Anthony P Monaco Genome Medicine 2010, 2:6 (26 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Four genes involved in specific language impairment have now been identified, highlighting a variety of neural pathways which contribute to the disorder.
	Review Downstream EWS/FLI1 - upstream Ewing's sarcoma Heinrich Kovar Genome Medicine 2010, 2:8 (28 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ewing's sarcoma family tumors express the fusion protein EWS/FLI1, modulation of which is a desirable therapeutic goal.
	Report
	Meeting report Genome informatics: advances in theory and practice Szu-chin Fu, Paul Horton Genome Medicine 2010, 2:7 (26 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 20th International Conference on Genome Informatics, Yokohama, Japan, 14-16 December 2009.
	Research
	Research Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia Nathan A Stephens, Iain J Gallagher, Olav Rooyackers, Richard J Skipworth, Ben H Tan, Troels Marstrand, James A Ross, Denis C Guttridge, Lars Lundell, Kenneth C Fearon, James A Timmons Genome Medicine 2010, 2:1 (15 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 2 comments \| Editor’s summary An 83-gene signature for cachexia in cancer patients includes genes such as CaMKII and TIE1 and suggests that preclinical models do not accurately reflect biological processes in human cancer cachexia.
	Method Family-based genetic risk prediction of multifactorial disease Douglas M Ruderfer, Joshua Korn, Shaun M Purcell Genome Medicine 2010, 2:2 (15 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Inclusion of phenotypic and genotypic information from close relatives in a genetic risk prediction model can lead to improved estimates of an individual’s disease risk.