Figure 2.

Age-related signaling network of cellular compartments. In this network representation, the elements of the network are the cellular compartments (PM, plasma membrane; ER, endoplasmic reticulum; MITO, mitochondria; GOLGI, the Golgi apparatus; NUCL, nucleus; PLASM, cytoplasm), while the links between them represent the age-related signaling pathways [30]. The network has been visualized using the Cytoscape program [21]. The colors represent the following pathways: orange, growth hormone pathways; green, MAP-kinase cascade; blue, dietary restriction pathway; red, reactive oxygen species.