Genome Medicine | Volume 1 Issue 8

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		Volume 1 Issue 8
		Comment
		Musings Musings on genome medicine: the value of family history Angus Clarke Genome Medicine 2009, 1:75 (3 August 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Family history information will not be made obsolete by genomic data both because it has broader uses and because it covers factors omitted by genomic tests.
		Review
		Review Linking genes to diseases: it's all in the data Nicki Tiffin, Miguel A Andrade-Navarro, Carolina Perez-Iratxeta Genome Medicine 2009, 1:77 (7 August 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Computational approaches to disease-gene associations, especially those that use phenotype ontologies, can help to prioritize the most likely candidate genes.
		Review Lithium: a key to the genetics of bipolar disorder Cristiana Cruceanu, Martin Alda, Gustavo Turecki Genome Medicine 2009, 1:79 (19 August 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Despite molecular studies of bipolar disorder and response to lithium treatment, neither the mechanism of lithium action nor the genetic profile of bipolar disorder is fully understood yet.
		Review Huntington's disease: the case for genetic modifiers James F Gusella, Marcy E MacDonald Genome Medicine 2009, 1:80 (21 August 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The search for genetic modifiers in Huntington’s disease offers insights into biochemical changes occurring years before diagnosis and may allow the identification of targets for therapeutic intervention.
		Minireview Genetic and genomic insights into age at natural menopause Francisco Moron, Agustin Ruiz, Jose Galan Genome Medicine 2009, 1:76 (6 August 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genetic factors involved in the variability in age at natural menopause may play a role in osteoporosis, cardiovascular disease and breast cancer, as well as infertility.
		Minireview The new molecular biology of granulosa cell tumors of the ovary Nicolas Kalfa, Reiner A Veitia, Bérénice A Benayoun, Brigitte Boizet-Bonhoure, Charles Sultan Genome Medicine 2009, 1:81 (25 August 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The gsp oncogene and the forkhead transcription factor FOXL2 are both implicated in the pathophysiology of granulosa cell tumors, providing new insights into ovarian function and granulosa cell tumor development.
		Report
		Meeting report MicroRNAs and cancer: what we know and what we still have to learn George A Calin Genome Medicine 2009, 1:78 (17 August 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Keystone Symposia on MicroRNAs and Cancer, Keystone, Colorado, CO, USA, 10-15 June 2009.