Genome Medicine | Volume 1 Issue 7

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	Volume 1 Issue 7
	Comment
	Commentary Genomic advances and their impact on clinical trial design Sumithra J Mandrekar, Daniel J Sargent Genome Med 2009, 1:69 (13 July 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genomic advances not only continually influence the design of new trials, but also affect the (re)design of ongoing trials.
	Commentary Genomic electronic health records: opportunities and challenges Mohammad Al-Ubaydli, Rob Navarro Genome Med 2009, 1:73 (22 July 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Patient health records should be stored in federated databases; such data sharing raises questions of ownership and stewardship that require social and political answers as well as consideration of the clinical and scientific benefits.
	Musings Musings on genome medicine: is there hope for ethical and safe stem cell therapeutics? Mahendra Rao, Maureen L Condic Genome Med 2009, 1:70 (14 July 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent advances in stem cell therapy may help the development of pluripotent cells that raise fewer ethical concerns, and continued advances are likely to allow therapy to be delivered in a safe and effective manner.
	Review
	Minireview Exploring the unknown: assumptions about allelic architecture and strategies for susceptibility variant discovery Mark I McCarthy Genome Medicine 2009, 1:66 (3 July 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Choosing a research strategy to identify causal variants for diseases means that implicit assumptions are made about the characteristics of the variants being sought and the genomic architecture of the disease under consideration.
	Review Oncoproteomic profiling with antibody microarrays Mohamed SS Alhamdani, Christoph Schröder, Jörg D Hoheisel Genome Med 2009, 1:68 (6 July 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Antibody microarrays are proving useful for the early detection, discrimination and monitoring of tumors, and they are becoming more sensitive and easier to use.
	Review Genetic susceptibility to psoriasis: an emerging picture Rhodri Smith, Richard B Warren, Christopher EM Griffiths, Jane Worthington Genome Med 2009, 1:72 (22 July 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genome-wide association studies have identified susceptibility loci for psoriasis which are shared with a variety of immune-based diseases including diabetes, Crohn's disease, asthma, and multiple sclerosis, raising hope for new and improved targeted therapies.
	Review The emerging molecular pathogenesis of neuroblastoma: implications for improved risk assessment and targeted therapy Nadine Van Roy, Katleen De Preter, Jasmien Hoebeeck, Tom Van Maerken, Filip Pattyn, Pieter Mestdagh, Joëlle Vermeulen, Jo Vandesompele, Frank Speleman Genome Med 2009, 1:74 (27 July 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Genomic, epigenetic and microRNA changes influence the development and severity of neuroblastoma, and copy number variations can now be used to form genomic subgroups which correlate with clinical outcome.
	Report
	Meeting report The 2009 European Society of Human Genetics Meeting: novel technologies driving change Andrew J Sharp Genome Medicine 2009, 1:67 (6 July 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the meeting of the European Society of Human Genetics, Vienna, Austria, 23-26 May, 2009.
	Meeting report The ethics and regulation of direct-to-consumer genetic testing Paula Boddington Genome Medicine 2009, 1:71 (20 July 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of a workshop 'Direct-to-consumer genetic testing: ethical and regulatory issues', Oxford, UK, 21 May 2009.