Translational bioinformatics applications in genome medicine
Stanford Center for Biomedical Informatics, Department of Medicine and Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA, and Lucile Packard Children's Hospital, Palo Alto, CA 94304, USA
Genome Medicine 2009, 1:64 doi:10.1186/gm64Published: 29 June 2009
Although investigators using methodologies in bioinformatics have always been useful in genomic experimentation in analytic, engineering, and infrastructure support roles, only recently have bioinformaticians been able to have a primary scientific role in asking and answering questions on human health and disease. Here, I argue that this shift in role towards asking questions in medicine is now the next step needed for the field of bioinformatics. I outline four reasons why bioinformaticians are newly enabled to drive the questions in primary medical discovery: public availability of data, intersection of data across experiments, commoditization of methods, and streamlined validation. I also list four recommendations for bioinformaticians wishing to get more involved in translational research.