Genome Medicine | Volume 1 Issue 6

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		Volume 1 Issue 6
		Comment
		Commentary Using a global proteomic approach to identify proteins affected by estrogen therapy Timothy D Veenstra Genome Medicine 2009, 1:58 (5 June 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Although global proteomic analyses involve a number of methodological challenges, they can substantially add to data gathered via other study designs by unveiling novel functional pathways and hypotheses that can help guide and prioritize further research.
		Commentary Translational bioinformatics applications in genome medicine Atul J Butte Genome Medicine 2009, 1:64 (29 June 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Investigators empowered by bioinformatics need to take on the role of translational scientist by building the tools to ask the questions that will yield discoveries which will improve human health.
		Musings Musings on genome medicine: cholesterol and coronary artery disease David G Nathan, Stuart H Orkin Genome Medicine 2009, 1:60 (8 June 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary We should not be distracted by inflammation, which is a secondary consequence of atherosclerosis and therefore less important than cholesterol in the pathogenesis of coronary artery disease.
		Review
		Minireview MicroRNAs sound off Michael D Weston, Garrett A Soukup Genome Medicine 2009, 1:59 (8 June 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary With increasing evidence showing that microRNA-96 is crucial to the development and maintenance of inner ear hair cells and hearing, interest in microRNAs as therapeutic agents or target molecules to preserve or restore hearing is growing.
		Minireview Using prior knowledge and genome-wide association to identify pathways involved in multiple sclerosis Marylyn D Ritchie Genome Medicine 2009, 1:65 (29 June 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The combination of pathway-based approaches and genome-wide association studies can help to detect important single-locus effects, as shown by a recent study on multiple sclerosis.
		Review Towards an integrated proteomic and glycomic approach to finding cancer biomarkers Allen D Taylor, William S Hancock, Marina Hincapie, Naoyuki Taniguchi, Samir M Hanash Genome Medicine 2009, 1:57 (4 June 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary New technologies are enabling the identification of glycosylation sites and glycans in proteins from complex proteomic mixtures, which will help to identify cancer biomarkers.
		Review Copy number variations and cancer Adam Shlien, David Malkin Genome Medicine 2009, 1:62 (16 June 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Germline and somatic copy number variations play an increasingly important role in both the predisposition to and the pathogenesis of cancer.
		Review Genomic and post-genomic analyses of human prion diseases Maurizio Pocchiari, Anna Poleggi, Serena Principe, Silvia Graziano, Franco Cardone Genome Medicine 2009, 1:63 (22 June 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genomic and post-genomic analyses have led to new insights in our understanding of human prion diseases and give new hope for patient therapy.
		Report
		Meeting report Biology of Genomes: making sense of sequence Daniel G MacArthur Genome Medicine 2009, 1:61 (12 June 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Biology of Genomes meeting held at Cold Spring Harbor Laboratory, NY, USA, 5-9 May 2009

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